The impact of the bone marrow microenvironment on multiple myeloma (Review)

  • Authors:
    • Jianhao Hou
    • Rongfang Wei
    • Jinjun Qian
    • Ronggen Wang
    • Zhimin Fan
    • Chunyan Gu
    • Ye Yang
  • View Affiliations

  • Published online on: August 5, 2019     https://doi.org/10.3892/or.2019.7261
  • Pages: 1272-1282
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Abstract

Multiple myeloma (MM) is characterized by the accumulation of monoclonal plasma cells in the bone marrow (BM). The interaction between the BM microenvironment and MM plasma cells can influence cell proliferation, drug resistance and prognosis of the disease. The BM microenvironment (BMME) consists of a cellular and non‑cellular compartment. The cellular compartment includes stromal cells, endothelial cells, osteoclasts and osteoblasts, and the non‑cellular compartment includes the extracellular matrix (ECM) and the liquid milieu, which contains cytokines, growth factors and chemokines. The complex interaction between the BM microenvironment and MM plasma cells influences disease development and prognosis. The present review focuses on the interaction between malignant plasma cells and the BM microenvironment during MM progression. An improved understanding of the interaction between MM plasma cells and their microenvironment will enable the development of novel therapeutic tools that can be used in the treatment of MM, a currently incurable blood cancer.

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October 2019
Volume 42 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Hou, J., Wei, R., Qian, J., Wang, R., Fan, Z., Gu, C., & Yang, Y. (2019). The impact of the bone marrow microenvironment on multiple myeloma (Review). Oncology Reports, 42, 1272-1282. https://doi.org/10.3892/or.2019.7261
MLA
Hou, J., Wei, R., Qian, J., Wang, R., Fan, Z., Gu, C., Yang, Y."The impact of the bone marrow microenvironment on multiple myeloma (Review)". Oncology Reports 42.4 (2019): 1272-1282.
Chicago
Hou, J., Wei, R., Qian, J., Wang, R., Fan, Z., Gu, C., Yang, Y."The impact of the bone marrow microenvironment on multiple myeloma (Review)". Oncology Reports 42, no. 4 (2019): 1272-1282. https://doi.org/10.3892/or.2019.7261