Open Access

Dietary baker's yeast sensitizes Ehrlich mammary adenocarcinoma to paclitaxel in mice bearing tumor

  • Authors:
    • Mamdooh Ghoneum
    • Nariman K. Badr El-Din
    • Ashraf Z. Mahmoud
    • Lucilene Tolentino
    • Deyu Pan
    • Tahia Ali Hassan
  • View Affiliations

  • Published online on: April 10, 2019     https://doi.org/10.3892/or.2019.7107
  • Pages: 3155-3166
  • Copyright: © Ghoneum et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Baker's yeast, Saccharomyces cerevisiae, has been shown to sensitize a variety of breast cancer cell (BCC) lines to paclitaxel chemotherapy in vitro. The present study evaluated the ability of S. cerevisiae to sensitize BCCs to paclitaxel in animals bearing Ehrlich ascites carcinoma (EAC). Mice bearing EAC were intratumorally injected with dead S. cerevisiae (1x107 cells/ml) in the presence or absence of low- and high-dose paclitaxel [paclitaxel-L, 2 mg/kg body weight (BW) and paclitaxel-H, 10 mg/kg BW, respectively]. At 30 days post tumor inoculation, co-treatment with yeast plus paclitaxel-L showed improvements over paclitaxel-H alone, as measured by tumor weight (-64 vs. -53%), DNA damage (+79 vs. +62%), tumor cell apoptosis (+217 vs. +177%), cell proliferation (-56 vs. -42%) and Ki-67 marker (+95 vs. +40%). Histopathology and ultra-structural examinations showed that yeast plus paclitaxel-L enhanced apoptosis in EAC more than paclitaxel-H alone and caused comparable tumor necrosis. We conclude that baker's yeast may be used with low-dose chemotherapy to achieve the same potency as high-dose chemotherapy in mice bearing EAC. This suggests that baker's yeast may be an anticancer adjuvant and may have clinical implications for the treatment of breast cancer.
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June 2019
Volume 41 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Ghoneum, M., Badr El-Din, N.K., Mahmoud, A.Z., Tolentino, L., Pan, D., & Hassan, T.A. (2019). Dietary baker's yeast sensitizes Ehrlich mammary adenocarcinoma to paclitaxel in mice bearing tumor. Oncology Reports, 41, 3155-3166. https://doi.org/10.3892/or.2019.7107
MLA
Ghoneum, M., Badr El-Din, N. K., Mahmoud, A. Z., Tolentino, L., Pan, D., Hassan, T. A."Dietary baker's yeast sensitizes Ehrlich mammary adenocarcinoma to paclitaxel in mice bearing tumor". Oncology Reports 41.6 (2019): 3155-3166.
Chicago
Ghoneum, M., Badr El-Din, N. K., Mahmoud, A. Z., Tolentino, L., Pan, D., Hassan, T. A."Dietary baker's yeast sensitizes Ehrlich mammary adenocarcinoma to paclitaxel in mice bearing tumor". Oncology Reports 41, no. 6 (2019): 3155-3166. https://doi.org/10.3892/or.2019.7107