Differential expression of miRNAs in esophageal cancer tissue

  • Authors:
    • Shang-Guo Liu
    • Xiu-Guang Qin
    • Bao-Sheng Zhao
    • Bo Qi
    • Wen‑Jian Yao
    • Tian-Yun Wang
    • Han-Chen Li
    • Xiang-Nan Wu
  • View Affiliations

  • Published online on: March 12, 2013     https://doi.org/10.3892/ol.2013.1251
  • Pages: 1639-1642
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Abstract

The aim of this study was to explore the association of specific microRNAs (miRNAs) with the development of esophageal cancer (EC) and to identify new molecular markers for EC by analyzing the expression profiles of miRNAs in EC tissues. The expression profiles of miRNAs in paired EC and paracancerous normal tissues were detected and bioinformatically analyzed using miRNA assays. The outcomes were validated using real-time polymerase chain reaction. The miRNA assays revealed a total of 60 differentially expressed miRNAs in the EC tissues compared with those in the paracancerous normal tissues. Among them, 51 had doubled or more than doubled their expression levels and 9 had halved their expression levels. The most markedly upregulated miRNAs were hsa-miR-15a, hsa-miR-28-3p, hsa-miR-31, hsa-miR-99b, hsa-miR-101, hsa-miR-130a, hsa-miR-143, hsa-miR-196b, hsa-miR-200a, hsa-miR-210, hsa-miR-452 and hsa-miR-27a, whereas the most markedly downregulated miRNAs included hsa-miR-30b, hsa-miR-223, hsa-miR-454, hsa-miR-486, hsa-miR-574-3p and hsa-miR-126. Specific miRNA expression profiles exist in EC tissues and may serve as novel EC molecular markers.

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May 2013
Volume 5 Issue 5

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Copy and paste a formatted citation
APA
Liu, S., Qin, X., Zhao, B., Qi, B., Yao, W., Wang, T. ... Wu, X. (2013). Differential expression of miRNAs in esophageal cancer tissue. Oncology Letters, 5, 1639-1642. https://doi.org/10.3892/ol.2013.1251
MLA
Liu, S., Qin, X., Zhao, B., Qi, B., Yao, W., Wang, T., Li, H., Wu, X."Differential expression of miRNAs in esophageal cancer tissue". Oncology Letters 5.5 (2013): 1639-1642.
Chicago
Liu, S., Qin, X., Zhao, B., Qi, B., Yao, W., Wang, T., Li, H., Wu, X."Differential expression of miRNAs in esophageal cancer tissue". Oncology Letters 5, no. 5 (2013): 1639-1642. https://doi.org/10.3892/ol.2013.1251