Open Access

Multiple primary malignant neoplasms: A case report and literature review

  • Authors:
    • Linwei Zhang
    • Lingxin Feng
    • Hui Cong
    • Zhuang Yu
    • Haocheng Wang
    • Ya Dong
    • Jing Wang
  • View Affiliations

  • Published online on: August 23, 2019     https://doi.org/10.3892/ol.2019.10779
  • Pages: 4210-4220
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Until recently, few cases of three or more malignant tumors in one patient have been reported. Owing to the high incidence rate of these tumors, the improvement in cancer diagnosis and treatment, and the extension of patient survival time, the incidence of reported multiple primary malignant neoplasms has gradually increased. The present study reported the case of a 57‑year‑old man with non‑small cell lung cancer combined with B‑Raf proto‑oncogene serine/threonine kinase V600E mutation, gastrointestinal stromal tumors and lumbar vertebral malignant mucinous sarcoma. The pathogenesis, diagnosis and treatment of these three malignancies are discussed and previous studies are also reviewed. The aim of the study was to analyze the genetic mutations associated with multiple primary malignant tumors and to discuss whether those mutations with unknown functional significance could be used as therapeutic indicators. This case report will serve as a reference for future treatment of such patients.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Zhang, L., Feng, L., Cong, H., Yu, Z., Wang, H., Dong, Y., & Wang, J. (2019). Multiple primary malignant neoplasms: A case report and literature review. Oncology Letters, 18, 4210-4220. https://doi.org/10.3892/ol.2019.10779
MLA
Zhang, L., Feng, L., Cong, H., Yu, Z., Wang, H., Dong, Y., Wang, J."Multiple primary malignant neoplasms: A case report and literature review". Oncology Letters 18.4 (2019): 4210-4220.
Chicago
Zhang, L., Feng, L., Cong, H., Yu, Z., Wang, H., Dong, Y., Wang, J."Multiple primary malignant neoplasms: A case report and literature review". Oncology Letters 18, no. 4 (2019): 4210-4220. https://doi.org/10.3892/ol.2019.10779