Open Access

Long non‑coding RNA urothelial cancer associated 1 can regulate the migration and invasion of colorectal cancer cells (SW480) via myocardin‑related transcription factor‑A

  • Authors:
    • Long Zhang
    • Chengcheng Zheng
    • Zhen Sun
    • Huaqing Wang
    • Fengwei Wang
  • View Affiliations

  • Published online on: August 9, 2019     https://doi.org/10.3892/ol.2019.10737
  • Pages: 4185-4193
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer (CRC) is the third leading cause of cancer‑associated mortalities. Long non‑coding RNAs (lncRNAs) have been identified as key regulators in the occurrence and development of CRC. The lncRNA urothelial cancer associated 1 (UCA1) has been demonstrated to promote the development of numerous different types of cancer. In the present study, a novel molecular mechanism of UCA1, regulating the migratory and invasive capabilities of SW480 CRC cells was identified. UCA1 promoted the migration and invasion of SW480 cells by suppressing phosphorylation of myocardin‑related transcription factor‑A (MRTF‑A). Our findings indicated that UCA1 competes with extracellular signal‑regulated kinases1/2 to inhibit the phosphorylation of MRTF‑A. These novel discoveries may reveal additional functions of UCA1, which may support future clinical development of novel drug targets.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Zhang, L., Zheng, C., Sun, Z., Wang, H., & Wang, F. (2019). Long non‑coding RNA urothelial cancer associated 1 can regulate the migration and invasion of colorectal cancer cells (SW480) via myocardin‑related transcription factor‑A. Oncology Letters, 18, 4185-4193. https://doi.org/10.3892/ol.2019.10737
MLA
Zhang, L., Zheng, C., Sun, Z., Wang, H., Wang, F."Long non‑coding RNA urothelial cancer associated 1 can regulate the migration and invasion of colorectal cancer cells (SW480) via myocardin‑related transcription factor‑A". Oncology Letters 18.4 (2019): 4185-4193.
Chicago
Zhang, L., Zheng, C., Sun, Z., Wang, H., Wang, F."Long non‑coding RNA urothelial cancer associated 1 can regulate the migration and invasion of colorectal cancer cells (SW480) via myocardin‑related transcription factor‑A". Oncology Letters 18, no. 4 (2019): 4185-4193. https://doi.org/10.3892/ol.2019.10737