Open Access

NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT

  • Authors:
    • Haining Meng
    • Junyu Wu
    • Qiao Huang
    • Xi Yang
    • Kunao Yang
    • Yuexin Qiu
    • Jiwen Ren
    • Ruowu Shen
    • Hong Qi
  • View Affiliations

  • Published online on: August 16, 2019     https://doi.org/10.3892/ol.2019.10756
  • Pages: 4022-4029
  • Copyright: © Meng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Neural precursor cell‑expressed, developmentally‑downregulated 9 (NEDD9) is a multi‑domain skeleton protein that serves an important role in the cell signaling process via modulating invasion, metastasis, proliferation and apoptosis of tumor cells. The present study identified that the expression levels of NEDD9 in colorectal cancer were elevated. Therefore, the effect of downregulating the expression of NEDD9 in terms of invasion and migration of colorectal cancer cells was investigated and the role of the JNK pathway in these processes was also investigated. The data revealed that downregulation of NEDD9 and JNK inhibitors suppressed invasion and migration, decreased expression levels of phosphorylated JNK, increased the expression levels of E‑cadherin and decreased the expression levels of vimentin. In summary, NEDD9 promotes invasion and migration of colorectal cancer cells via the JNK pathway.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Meng, H., Wu, J., Huang, Q., Yang, X., Yang, K., Qiu, Y. ... Qi, H. (2019). NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT. Oncology Letters, 18, 4022-4029. https://doi.org/10.3892/ol.2019.10756
MLA
Meng, H., Wu, J., Huang, Q., Yang, X., Yang, K., Qiu, Y., Ren, J., Shen, R., Qi, H."NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT". Oncology Letters 18.4 (2019): 4022-4029.
Chicago
Meng, H., Wu, J., Huang, Q., Yang, X., Yang, K., Qiu, Y., Ren, J., Shen, R., Qi, H."NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT". Oncology Letters 18, no. 4 (2019): 4022-4029. https://doi.org/10.3892/ol.2019.10756