Open Access

Role of non‑coding RNA in pancreatic cancer (Review)

  • Authors:
    • Yinghao Lv
    • Shuai Huang
  • View Affiliations

  • Published online on: August 16, 2019     https://doi.org/10.3892/ol.2019.10758
  • Pages: 3963-3973
  • Copyright: © Lv et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pancreatic cancer is a malignant disease that develops rapidly and carries a poor prognosis. Currently, surgery is the only radical treatment. Non‑coding RNAs (ncRNAs) are protein‑free RNAs produced by genome transcription; they play important roles in regulating gene expression, participating in epigenetic modification, cell proliferation, differentiation and reproduction. ncRNAs also play key roles in the development of cancer; microRNA (miRNA) and long non‑coding RNA (lncRNA) may lead the way to new treatments for pancreatic cancer. miRNAs are short‑chain ncRNAs (19‑24 nt) that inhibit the degradation of protein translation or their target gene mRNAs to regulate gene expression. lncRNAs contain >200 nt of ncRNA and play important regulatory roles in a number of malignant tumors, in terms of tumor cell proliferation, apoptosis, invasion and distant metastasis. lncRNAs can be exploited for the diagnosis and treatment of pancreatic cancer and have substantial prospects for clinical application. Nevertheless, the molecular mechanism of their regulation and function, as well as the significance of other ncRNAs, such as piwi‑interacting RNA, in the pathogenesis of pancreatic cancer, are largely unknown. In this review, the structures of ncRNAs with various classifications, as well as the functions and important roles of ncRNAs in the diagnosis and treatment of pancreatic cancer are reviewed.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Lv, Y., & Lv, Y. (2019). Role of non‑coding RNA in pancreatic cancer (Review). Oncology Letters, 18, 3963-3973. https://doi.org/10.3892/ol.2019.10758
MLA
Lv, Y., Huang, S."Role of non‑coding RNA in pancreatic cancer (Review)". Oncology Letters 18.4 (2019): 3963-3973.
Chicago
Lv, Y., Huang, S."Role of non‑coding RNA in pancreatic cancer (Review)". Oncology Letters 18, no. 4 (2019): 3963-3973. https://doi.org/10.3892/ol.2019.10758