Open Access

Role of stanniocalcin‑1 in breast cancer (Review)

  • Authors:
    • Fengxia Chen
    • Zhicai Zhang
    • Feifei Pu
  • View Affiliations

  • Published online on: August 22, 2019     https://doi.org/10.3892/ol.2019.10777
  • Pages: 3946-3953
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer is a highly heterogeneous disease consisting of five disease subtypes with distinct histological characteristics, clinical behaviors and prognostic features. Stanniocalcin‑1 (STC1) is a secreted glycoprotein hormone that has been demonstrated to regulate calcium and phosphate homeostasis. Mammalian STC1 is expressed in various tissues and is implicated in multiple physiological and pathophysiological processes. In addition, growing evidence has suggested that STC1 serves an oncogenic role in a number of different types of tumor. However, the role of STC1 in breast cancer is complex, considering that some studies have shown that it exerts an oncogenic role, whereas other studies have demonstrated the opposite. The aim of the present review article is to evaluate the currently available data on mammalian STC1 and discuss its potential roles in each subtype of breast cancer.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Chen, F., Zhang, Z., & Pu, F. (2019). Role of stanniocalcin‑1 in breast cancer (Review). Oncology Letters, 18, 3946-3953. https://doi.org/10.3892/ol.2019.10777
MLA
Chen, F., Zhang, Z., Pu, F."Role of stanniocalcin‑1 in breast cancer (Review)". Oncology Letters 18.4 (2019): 3946-3953.
Chicago
Chen, F., Zhang, Z., Pu, F."Role of stanniocalcin‑1 in breast cancer (Review)". Oncology Letters 18, no. 4 (2019): 3946-3953. https://doi.org/10.3892/ol.2019.10777