Vitamin C induces human melanoma A375 cell apoptosis via Bax‑ and Bcl‑2‑mediated mitochondrial pathways

  • Authors:
    • Xiao‑Yu Chen
    • Ying Chen
    • Chuan‑Jun Qu
    • Zhao‑Hai Pan
    • Yao Qin
    • Xin Zhang
    • Wen‑Jing Liu
    • De‑Fang Li
    • Qiusheng Zheng
  • View Affiliations

  • Published online on: July 29, 2019     https://doi.org/10.3892/ol.2019.10686
  • Pages: 3880-3886
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Abstract

Melanoma is the most malignant type of skin cancer and is resistant to numerous chemotherapeutic and radiotherapy‑based treatment approaches due to the activation of rapid and reversible pro‑survival signaling pathways. As a result, patients will often present with a poor prognosis. Therefore, novel preventive methods and treatments are urgently required for patients with melanoma. Vitamin C (also known as L‑ascorbic acid) is a water‑soluble vitamin that is widely used as a dietary additive and has been demonstrated to exhibit anti‑cancer properties. In the present study, the effects of vitamin C in human melanoma A375 cells, and the mechanisms underlying these effects were investigated. Vitamin C potently suppressed human melanoma A375 cell proliferation by inducing apoptosis in A375 cells. Induction of apoptosis was related to caspase‑9 and caspase‑3 activation and the mitochondrial membrane potential of A375 cells significantly decreased in the presence of vitamin C. Furthermore, vitamin C induced apoptosis in A375 cells by activating the Bax‑ and Bcl‑2‑mediated mitochondrial pathway. These results indicate that vitamin C may be a potentially useful clinical anti‑tumor drug for treating patients with melanoma.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Chen, X., Chen, Y., Qu, C., Pan, Z., Qin, Y., Zhang, X. ... Zheng, Q. (2019). Vitamin C induces human melanoma A375 cell apoptosis via Bax‑ and Bcl‑2‑mediated mitochondrial pathways. Oncology Letters, 18, 3880-3886. https://doi.org/10.3892/ol.2019.10686
MLA
Chen, X., Chen, Y., Qu, C., Pan, Z., Qin, Y., Zhang, X., Liu, W., Li, D., Zheng, Q."Vitamin C induces human melanoma A375 cell apoptosis via Bax‑ and Bcl‑2‑mediated mitochondrial pathways". Oncology Letters 18.4 (2019): 3880-3886.
Chicago
Chen, X., Chen, Y., Qu, C., Pan, Z., Qin, Y., Zhang, X., Liu, W., Li, D., Zheng, Q."Vitamin C induces human melanoma A375 cell apoptosis via Bax‑ and Bcl‑2‑mediated mitochondrial pathways". Oncology Letters 18, no. 4 (2019): 3880-3886. https://doi.org/10.3892/ol.2019.10686