Open Access

Long non‑coding RNA mortal obligate RNA transcript suppresses tumor cell proliferation in prostate carcinoma by inhibiting glucose uptake

  • Authors:
    • Zhenfeng Shi
    • Feng Guo
    • Deyong Jia
    • Jinxing Huang
    • Jie Chen
    • Min Sun
    • Feibo Qi
    • Chengyuan Liang
  • View Affiliations

  • Published online on: August 5, 2019     https://doi.org/10.3892/ol.2019.10711
  • Pages: 3787-3791
  • Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

A previous study reported the decreased expression of long non‑coding RNA mortal obligate RNA transcript (lncRNA MORT) in 16 types of cancer, while the functionality of lncRNA MORT in cancer biology remains unknown. Therefore, the present study was conducted to characterize the functionality of lncRNA MORT in prostate carcinoma, a common cancer type worldwide. lncRNA MORT expression level was downregulated in tumor tissues compared with that in the adjacent healthy tissues of patients with prostate carcinoma. Expression of lncRNA MORT in tumor tissues was influenced by tumor size, but not by tumor metastasis. Overexpression of lncRNA MORT inhibited glucose uptake and glucose transporter 1 (GLUT‑1) expression in prostate carcinoma cell lines; GLUT‑1 overexpression upregulated glucose uptake and attenuated the effects of lncRNA MORT overexpression on glucose uptake, but did not significantly affect the expression of lncRNA MORT. Overexpression of lncRNA MORT inhibited, while GLUT‑1 overexpression promoted the proliferation of prostate carcinoma cells. In addition, GLUT‑1 overexpression attenuated the effects of lncRNA MORT on cell proliferation. Therefore, lncRNA MORT may inhibit cancer cell proliferation in prostate carcinoma by preventing glucose uptake.

Related Articles

Journal Cover

October 2019
Volume 18 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Shi, Z., Guo, F., Jia, D., Huang, J., Chen, J., Sun, M. ... Liang, C. (2019). Long non‑coding RNA mortal obligate RNA transcript suppresses tumor cell proliferation in prostate carcinoma by inhibiting glucose uptake. Oncology Letters, 18, 3787-3791. https://doi.org/10.3892/ol.2019.10711
MLA
Shi, Z., Guo, F., Jia, D., Huang, J., Chen, J., Sun, M., Qi, F., Liang, C."Long non‑coding RNA mortal obligate RNA transcript suppresses tumor cell proliferation in prostate carcinoma by inhibiting glucose uptake". Oncology Letters 18.4 (2019): 3787-3791.
Chicago
Shi, Z., Guo, F., Jia, D., Huang, J., Chen, J., Sun, M., Qi, F., Liang, C."Long non‑coding RNA mortal obligate RNA transcript suppresses tumor cell proliferation in prostate carcinoma by inhibiting glucose uptake". Oncology Letters 18, no. 4 (2019): 3787-3791. https://doi.org/10.3892/ol.2019.10711