Open Access

Association between RNF2+P‑AKT expression in pretreatment biopsy specimens, and poor survival following radiotherapy in patients with esophageal squamous cell carcinoma

  • Authors:
    • Qiaofang Li
    • Shuguang Li
    • Xingxiao Yang
    • Xueyuan Zhang
    • Chunyang Song
    • Shuchai Zhu
  • View Affiliations

  • Published online on: August 7, 2019     https://doi.org/10.3892/ol.2019.10727
  • Pages: 3734-3742
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The protein expression levels of Ring finger protein 2 (RNF2) and phosphor‑protein kinase B (P‑AKT) were determined in esophageal squamous cell carcinoma (ESCC) tissues, and the association between patient clinicopathological characteristics and survival time following definitive intensity‑modulated radiotherapy was assessed. Cancerous biopsy tissues were collected from patients with ESCC at The Fourth Affiliated Hospital of Hebei Medical University between January 2010 and December 2013. Of these 99 cases, 83 were used to analyze the protein expression level of RNF2 (89.2% positive), 85 for P‑AKT (65.9% positive) and 80 for RNF2+P‑AKT protein expression levels (62.5% both positive). The expression levels of RNF2 protein in ESCC were associated with tumor volume (P=0.024), whilst those of P‑AKT and RNF2+PAKT were associated with sex (P=0.041 and P=0.003, respectively). There were no significant differences in overall survival (OS) or progression‑free survival (PFS) rate between the RNF2‑ and the RNF2+‑+++ groups (P=0.134 and P=0.366, respectively), or between the P‑AKT‑ group and P‑AKT+‑+++ group (P=0.468; P=0.580, respectively). The 1‑, 3‑ and 5‑year OS rates were 68.0, 28.0, and 20.0%, and 86.7, 53.3, and 31.1%, in the RNF2/P‑AKT+ group and Other group, respectively (χ2=4.205; P=0.040). Multivariate analysis revealed that age, T stage and RNF2+P‑AKT expression were independent prognostic factors for ESCC (P=0.010, P=0.008 and P=0.010, respectively). The expression of RNF2+P‑AKT combined was an independent prognostic factor affecting survival rate, and therefore presents a potential prognostic indicator for patients with ESCC, treated with definitive radiotherapy.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Li, Q., Li, S., Yang, X., Zhang, X., Song, C., & Zhu, S. (2019). Association between RNF2+P‑AKT expression in pretreatment biopsy specimens, and poor survival following radiotherapy in patients with esophageal squamous cell carcinoma. Oncology Letters, 18, 3734-3742. https://doi.org/10.3892/ol.2019.10727
MLA
Li, Q., Li, S., Yang, X., Zhang, X., Song, C., Zhu, S."Association between RNF2+P‑AKT expression in pretreatment biopsy specimens, and poor survival following radiotherapy in patients with esophageal squamous cell carcinoma". Oncology Letters 18.4 (2019): 3734-3742.
Chicago
Li, Q., Li, S., Yang, X., Zhang, X., Song, C., Zhu, S."Association between RNF2+P‑AKT expression in pretreatment biopsy specimens, and poor survival following radiotherapy in patients with esophageal squamous cell carcinoma". Oncology Letters 18, no. 4 (2019): 3734-3742. https://doi.org/10.3892/ol.2019.10727