Open Access

Elevated CD44 expression predicts poor prognosis in patients with low‑grade glioma

  • Authors:
    • Qiang Dong
    • Qiao Li
    • Maolin Wang
    • Jianhong Hu
    • Junqiang Dai
    • Liang Niu
    • Guoqiang Yuan
    • Yawen Pan
  • View Affiliations

  • Published online on: August 7, 2019     https://doi.org/10.3892/ol.2019.10728
  • Pages: 3698-3704
  • Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

CD44 is involved in malignant processes including cell motility, tumor growth and angiogenesis. To explore the potential role of CD44 as a prognostic biomarker in low grade gliomas (LGG), the mRNA expression levels of CD44 in tissues from 12 patients with glioma were evaluated by microarray analysis. The mRNA level of CD44 in LGG and glioblastoma multiforme (GBM) were analyzed using datasets downloaded from the publicly available Oncomine database. Reverse transcription‑quantitative PCR and western blotting were used to further analyze the CD44 expression level in a set of 53 patients. Kaplan‑Meier analysis was performed to identify the prognostic roles of CD44 mRNA in LGG and GBM, with data obtained from the OncoLnc and Gene Expression Profiling Interactive Analysis databases and clinical follow‑ups. The present results revealed that CD44 mRNA expression levels were elevated in LGG and GBM compared with normal brain tissues. Furthermore, increased CD44 expression was associated with poor survival rates in LGG. The present study suggested that CD44 may act as an independent prognostic factor for LGG, and may be a potential therapeutic target for gliomas.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Dong, Q., Li, Q., Wang, M., Hu, J., Dai, J., Niu, L. ... Pan, Y. (2019). Elevated CD44 expression predicts poor prognosis in patients with low‑grade glioma. Oncology Letters, 18, 3698-3704. https://doi.org/10.3892/ol.2019.10728
MLA
Dong, Q., Li, Q., Wang, M., Hu, J., Dai, J., Niu, L., Yuan, G., Pan, Y."Elevated CD44 expression predicts poor prognosis in patients with low‑grade glioma". Oncology Letters 18.4 (2019): 3698-3704.
Chicago
Dong, Q., Li, Q., Wang, M., Hu, J., Dai, J., Niu, L., Yuan, G., Pan, Y."Elevated CD44 expression predicts poor prognosis in patients with low‑grade glioma". Oncology Letters 18, no. 4 (2019): 3698-3704. https://doi.org/10.3892/ol.2019.10728