Open Access

Dysregulation of N6‑methyladenosine regulators predicts poor patient survival in mantle cell lymphoma

  • Authors:
    • Weilong Zhang
    • Xue He
    • Jing Hu
    • Ping Yang
    • Cuiling Liu
    • Jing Wang
    • Ran An
    • Jingfei Zhen
    • Meng Pang
    • Kai Hu
    • Xiaoyan Ke
    • Xiuru Zhang
    • Hongmei Jing
  • View Affiliations

  • Published online on: August 2, 2019     https://doi.org/10.3892/ol.2019.10708
  • Pages: 3682-3690
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

N6‑methyladenosine (m6A) is the most abundant eukaryote mRNA modification, modulated by regulators known as epigenetic writers, erasers and readers, which are known to serve crucial roles in mRNA metabolism. However, the role of m6A during B‑cell development and B‑cell tumorigenesis remains poorly understood. By analyzing the gene expression profile of 123 mantle cell lymphoma cases from the Gene Expression Omnibus database, the present study demonstrated that one‑half of the m6A regulators were able to predict patient survival in mantle cell lymphoma, notably the m6A.index. The expression levels of the m6A regulators were regarded as good classifiers in mantle cell lymphoma. The m6A.index‑low mantle cell lymphoma type exhibited a poor patient survival and lower mRNA levels from the total transcriptome. The m6A regulators may be associated with the cell division and the RNA metabolic pathways, which may result in poor survival of patients with mantle cell lymphoma.

Related Articles

Journal Cover

October 2019
Volume 18 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Zhang, W., He, X., Hu, J., Yang, P., Liu, C., Wang, J. ... Jing, H. (2019). Dysregulation of N6‑methyladenosine regulators predicts poor patient survival in mantle cell lymphoma. Oncology Letters, 18, 3682-3690. https://doi.org/10.3892/ol.2019.10708
MLA
Zhang, W., He, X., Hu, J., Yang, P., Liu, C., Wang, J., An, R., Zhen, J., Pang, M., Hu, K., Ke, X., Zhang, X., Jing, H."Dysregulation of N6‑methyladenosine regulators predicts poor patient survival in mantle cell lymphoma". Oncology Letters 18.4 (2019): 3682-3690.
Chicago
Zhang, W., He, X., Hu, J., Yang, P., Liu, C., Wang, J., An, R., Zhen, J., Pang, M., Hu, K., Ke, X., Zhang, X., Jing, H."Dysregulation of N6‑methyladenosine regulators predicts poor patient survival in mantle cell lymphoma". Oncology Letters 18, no. 4 (2019): 3682-3690. https://doi.org/10.3892/ol.2019.10708