Open Access

Correlation analysis of expression and prognosis of TTF‑1 and CD44v6 in undifferentiated lung carcinoma

  • Authors:
    • Yudong Wu
    • Xia Yu
    • Mingzhu Liang
    • Baojun Wang
  • View Affiliations

  • Published online on: July 30, 2019     https://doi.org/10.3892/ol.2019.10689
  • Pages: 3571-3580
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Abstract

The correlation between expression and prognosis of thyroid transcription factor‑1 (TTF‑1) and CD44v6 in undifferentiated lung carcinoma was investigated. There were 116 cases with large cell undifferentiated carcinoma in group A, 120 cases with small cell undifferentiated carcinoma in group B and 80 normal individuals from the same period in group C. The expression levels of TTF‑1 and CD44v6 in the serum of group A, B and C and the cancer tissues and adjacent tissues of group A, B and C were detected using enzyme‑linked immunosorbent assay (ELISA), and the levels in each group were compared. Pearson's test was used to analyze the correlation between TTF‑1 and CD44v6 expression in serum of group A and group B and cancer tissues. Patients were divided into the survival group and the deceased group according to their 5‑year survival. Multivariate logistic regression was applied to analyze the risk factors of mortality, and receiver operating characteristic curve (ROC) was used to analyze the diagnostic value of TTF‑1 and CD44v6. The best cut‑off values of TTF‑1 and CD44v6 were divided into the high and low expression groups to observe the 5‑year mortality of patients and the Kaplan‑Meier (K‑M) survival curve was drawn. Multivariate logistic regression was used to analyze the risk factors of mortality. The expression of CD44v6 in the serum of group A and group B was higher than that in group C, and that of group B was higher than that in group A (P<0.05). The expression of TTF‑1 in serum of group A and group B was higher than that of group C, and the expression of TTF‑1 in group A was higher than that in group B (P<0.05). The expression of TTF‑1 and CD44v6 in group A and group B were significantly higher than those in adjacent tissues (P<0.05). The expression of TTF‑1 in group A was higher than that in group B (P<0.05), and that of CD44v6 was lower than that in group B (P<0.05). The 5‑year survival of patients showed that 209 patients died and 27 survived at 5 years; the survival rate was 11.44%. The course of disease, TNM stage, TTF‑1 and CD44v6 were independent mortality factors for undifferentiated lung cancer.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Wu, Y., Yu, X., Liang, M., & Wang, B. (2019). Correlation analysis of expression and prognosis of TTF‑1 and CD44v6 in undifferentiated lung carcinoma. Oncology Letters, 18, 3571-3580. https://doi.org/10.3892/ol.2019.10689
MLA
Wu, Y., Yu, X., Liang, M., Wang, B."Correlation analysis of expression and prognosis of TTF‑1 and CD44v6 in undifferentiated lung carcinoma". Oncology Letters 18.4 (2019): 3571-3580.
Chicago
Wu, Y., Yu, X., Liang, M., Wang, B."Correlation analysis of expression and prognosis of TTF‑1 and CD44v6 in undifferentiated lung carcinoma". Oncology Letters 18, no. 4 (2019): 3571-3580. https://doi.org/10.3892/ol.2019.10689