Open Access

Sulfasalazine suppresses thyroid cancer cell proliferation and metastasis through T‑cell originated protein kinase

  • Authors:
    • Ling Zou
    • Zhi Gao
    • Fanfan Zeng
    • Juanjuan Xiao
    • Junmei Chen
    • Xiaohong Feng
    • Di Chen
    • Ying Fang
    • Jing Cui
    • Yang Liu
    • Zhi Li
    • Feng Zhu
    • Qiuhong Duan
    • Xuan Lin
  • View Affiliations

  • Published online on: August 6, 2019     https://doi.org/10.3892/ol.2019.10721
  • Pages: 3517-3526
  • Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Thyroid cancer patients with radioactive iodine‑refractory or rapidly progressing presentation require effective treatment. T‑cell originated protein kinase (TOPK) is highly expressed in a number of different tumor types, where it promotes proliferation and metastasis. However, the expression of TOPK in thyroid cancer is poorly documented. Therefore, immunohistochemistry was used to detect the expression of TOPK in thyroid cancer tissues, and its clinical significance in this disease was investigated. Sulfasalazine, a targeted inhibitor of TOPK that directly binds the protein with a dissociation constant (Kd) of 228 µM, was also investigated using microscale thermophoresis. Sulfasalazine inhibited TOPK activity, as determined by an in vitro pull‑down assay. Furthermore, sulfasalazine inhibited the proliferation and metastasis of thyroid cancer cells. The results indicated that TOPK may be a potential therapeutic target and diagnostic biomarker for thyroid cancer and may be used as an index to evaluate malignant thyroid nodules. Therefore, sulfasalazine is a potential novel compound for the targeted treatment of thyroid cancer.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Zou, L., Gao, Z., Zeng, F., Xiao, J., Chen, J., Feng, X. ... Lin, X. (2019). Sulfasalazine suppresses thyroid cancer cell proliferation and metastasis through T‑cell originated protein kinase. Oncology Letters, 18, 3517-3526. https://doi.org/10.3892/ol.2019.10721
MLA
Zou, L., Gao, Z., Zeng, F., Xiao, J., Chen, J., Feng, X., Chen, D., Fang, Y., Cui, J., Liu, Y., Li, Z., Zhu, F., Duan, Q., Lin, X."Sulfasalazine suppresses thyroid cancer cell proliferation and metastasis through T‑cell originated protein kinase". Oncology Letters 18.4 (2019): 3517-3526.
Chicago
Zou, L., Gao, Z., Zeng, F., Xiao, J., Chen, J., Feng, X., Chen, D., Fang, Y., Cui, J., Liu, Y., Li, Z., Zhu, F., Duan, Q., Lin, X."Sulfasalazine suppresses thyroid cancer cell proliferation and metastasis through T‑cell originated protein kinase". Oncology Letters 18, no. 4 (2019): 3517-3526. https://doi.org/10.3892/ol.2019.10721