Open Access

Cross‑disease analysis identified novel common genes for both lung adenocarcinoma and lung squamous cell carcinoma

  • Authors:
    • Guanghui Zhang
    • Weijie Wang
    • Weiyang Huang
    • Xiaoli Xie
    • Zhigang Liang
    • Hongbao Cao
  • View Affiliations

  • Published online on: July 29, 2019     https://doi.org/10.3892/ol.2019.10678
  • Pages: 3463-3470
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung squamous cell carcinoma (LSCC) exhibits a number of similarities with lung adenocarcinoma (LA) in terms of copy number alterations. However, compared with LA, the range of genetic alterations in LSCC is less understood. In the present study, a large‑scale literature‑based search of LA‑associated genes and LSCC‑associated genes was performed to identify the genetic basis in common with these two diseases. For each of the LA‑associated genes, a mega‑analysis was performed to test its expression variations in LSCC using 11 RNA expression datasets, with significant genes identified using statistical analysis. Subsequently, a functional pathway analysis was performed to identify a possible association between any of the significant genes identified from the mega‑analysis and LSCC, followed by a co‑expression analysis. A multiple linear regression (MLR) model was employed to investigate the possible influence of sample size, country of origin and study date on gene expression in patients with LSCC. Disease‑gene association data analysis identified 1,178 genes involved in LA, 334 in LSCC, with a significant overlap of 187 genes (P<1.02x‑161). Mega‑analysis revealed that three LA‑associated genes, such as solute carrier family 2 member 1 (SLC2A1), endothelial PAS domain protein 1 (EPAS1) and cyclin‑dependent kinase 4 (CDK4), were significantly associated with LSCC (P<1.60x10‑8), with multiple potential pathways identified by functional pathway analysis, which were further validated by co‑expression analysis. The present MLR analysis suggested that the country of origin was a significant factor for the levels of expression of all three genes in patients with LSCC (P<4.0x10‑3). Collectively, the present results suggested that genes associated with LA should be further investigated for their association with LSCC. In addition, SLC2A1, EPAS1 and CDK4 may be novel risk genes associated with LA and LSCC.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Zhang, G., Wang, W., Huang, W., Xie, X., Liang, Z., & Cao, H. (2019). Cross‑disease analysis identified novel common genes for both lung adenocarcinoma and lung squamous cell carcinoma. Oncology Letters, 18, 3463-3470. https://doi.org/10.3892/ol.2019.10678
MLA
Zhang, G., Wang, W., Huang, W., Xie, X., Liang, Z., Cao, H."Cross‑disease analysis identified novel common genes for both lung adenocarcinoma and lung squamous cell carcinoma". Oncology Letters 18.4 (2019): 3463-3470.
Chicago
Zhang, G., Wang, W., Huang, W., Xie, X., Liang, Z., Cao, H."Cross‑disease analysis identified novel common genes for both lung adenocarcinoma and lung squamous cell carcinoma". Oncology Letters 18, no. 4 (2019): 3463-3470. https://doi.org/10.3892/ol.2019.10678