Open Access

Cervical cancer stem cells and other leading factors associated with cervical cancer development (Review)

  • Authors:
    • Gretel Mendoza‑Almanza
    • Elizabeth Ortíz‑Sánchez
    • Leticia Rocha‑Zavaleta
    • César Rivas‑Santiago
    • Edgar Esparza‑Ibarra
    • Jorge Olmos
  • View Affiliations

  • Published online on: August 6, 2019     https://doi.org/10.3892/ol.2019.10718
  • Pages: 3423-3432
  • Copyright: © Mendoza‑Almanza et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical cancer (CC) is one of the leading causes of cancer‑associated mortalities in women from developing countries. Similar to other types of cancer, CC is considered to be a multifactorial disease, involving socioeconomic, cultural, immunological and epigenetic factors, as well as persistent human papilloma virus (HPV) infection. It has been well established that cancer stem cells (CSCs) play an important role in defining tumor size, the speed of development and the level of regression following treatment; therefore, CSCs are associated with a poor prognosis. CSCs have been detected in many types of cancer, including leukemia, pancreatic, colon, esophagus, liver, prostate, breast, gastric and lung cancer. In cervical cancer, CSCs have been associated with resistance to normally used drugs such as cisplatin. The present review summarizes the strategies that high‑risk HPV viruses (HPV‑16 and HPV‑18) have developed to transform normal epithelial cells into cancer cells, as well as the cellular pathways and studies associated with the identification of cervical cancer stem cell biomarkers. In this sense, the present review provides state of the art information regarding CC development.

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October 2019
Volume 18 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Mendoza‑Almanza, G., Ortíz‑Sánchez, E., Rocha‑Zavaleta, L., Rivas‑Santiago, C., Esparza‑Ibarra, E., & Olmos, J. (2019). Cervical cancer stem cells and other leading factors associated with cervical cancer development (Review). Oncology Letters, 18, 3423-3432. https://doi.org/10.3892/ol.2019.10718
MLA
Mendoza‑Almanza, G., Ortíz‑Sánchez, E., Rocha‑Zavaleta, L., Rivas‑Santiago, C., Esparza‑Ibarra, E., Olmos, J."Cervical cancer stem cells and other leading factors associated with cervical cancer development (Review)". Oncology Letters 18.4 (2019): 3423-3432.
Chicago
Mendoza‑Almanza, G., Ortíz‑Sánchez, E., Rocha‑Zavaleta, L., Rivas‑Santiago, C., Esparza‑Ibarra, E., Olmos, J."Cervical cancer stem cells and other leading factors associated with cervical cancer development (Review)". Oncology Letters 18, no. 4 (2019): 3423-3432. https://doi.org/10.3892/ol.2019.10718