Tanshinone IIA inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via p53‑cyclin B1/CDC2

  • Authors:
    • Bin Liu
    • Lixia Liu
    • Aimin Zang
    • Zizheng Song
    • Hua Yang
    • Zhiyu Wang
    • Yanhong Shang
    • Tao Ma
    • Yonggang Zhang
  • View Affiliations

  • Published online on: July 24, 2019     https://doi.org/10.3892/ol.2019.10658
  • Pages: 3317-3322
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Abstract

Tanshinone IIA exhibits natural antioxidative and antineoplastic activity. However, to the best of our knowledge, the effects of tanshinone IIA on human nasopharyngeal carcinoma cells remains unknown. The present study aimed to investigate whether tanshinone IIA inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via p53‑cyclin B1/cell division cycle gene 2 (CDC2). Cell proliferation, cytotoxicity and apoptosis of 13‑9B cells were evaluated by an MTT assay, lactate dehydrogenase assay and flow cytometry, respectively. ELISA and western blot analysis were used to analyze caspase‑3 activity and poly (ADP‑ribose) polymerase (PARP), p53, cyclin B1 and CDC2 protein expression in 13‑9B cells. Treatment of 13‑9B cells with tanshinone IIA significantly suppressed cell proliferation and significantly induced cytotoxicity and apoptosis of 13‑9B cells. Furthermore, tanshinone IIA significantly increased caspase‑3 activity, and significantly increased the protein expression levels of PARP, p53, cyclin B1 and CDC2 in 13‑9B cells. In summary, the current results indicate that tanshinone IIA inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via PARP, p53, cyclin B1/CDC2 and caspase‑3‑mediated signaling.
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September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Liu, B., Liu, L., Zang, A., Song, Z., Yang, H., Wang, Z. ... Zhang, Y. (2019). Tanshinone IIA inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via p53‑cyclin B1/CDC2. Oncology Letters, 18, 3317-3322. https://doi.org/10.3892/ol.2019.10658
MLA
Liu, B., Liu, L., Zang, A., Song, Z., Yang, H., Wang, Z., Shang, Y., Ma, T., Zhang, Y."Tanshinone IIA inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via p53‑cyclin B1/CDC2". Oncology Letters 18.3 (2019): 3317-3322.
Chicago
Liu, B., Liu, L., Zang, A., Song, Z., Yang, H., Wang, Z., Shang, Y., Ma, T., Zhang, Y."Tanshinone IIA inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via p53‑cyclin B1/CDC2". Oncology Letters 18, no. 3 (2019): 3317-3322. https://doi.org/10.3892/ol.2019.10658