Open Access

Short-term efficacy and safety of MR-guided focused ultrasound surgery for analgesia in children with metastatic bone tumors

  • Authors:
    • Bo Wang
    • Jianning Li
    • Xinhong Wei
  • View Affiliations

  • Published online on: July 18, 2019     https://doi.org/10.3892/ol.2019.10628
  • Pages: 3283-3289
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Short-term efficacy and safety of magnetic resonance-guided focused ultrasound surgery (MRgFUS) for analgesia in children with metastatic bone tumors were studied. Thirty children with pediatric bone metastases admitted to Jinan Maternity and Child Care Hospital from March 2015 to March 2018 and who received MRgFUS treatment of the bone metastasis lesions were collected. The postoperative efficacy was assessed. The observation indicators included the Numerical Rating Scale (NRS) scores, European Organization for Research and Treatment of Cancer (EORTC) and Quality of Life Questionnaire (QLQ) scores before surgery, and 1 week, 1, 2, and 3 months after surgery and the Karnofsky Performance Status (KPS) scores before surgery, and 1 week and 3 months after surgery. The adverse reactions and medications of the children after the surgery were also under observation. NRS and VAS scores of all different observation time-points after surgery were statistically lower than those before surgery (P<0.05), and the NRS scores and Visual Analog Scale (VAS) scores 3 months after surgery were lower than those 1 week after surgery (P<0.05). Compared with the preoperative conditions, the QLQ-C30 scores of terms like physical function, cognitive function, nausea and vomiting, and degree of pain 1 week, 1, 2, and 3 months after surgery were decreased, and the clinical symptoms of the children were relieved (P<0.05). There was a statistical difference between the total QLQ-C30 scores 3 months after operation and the total QLQ-C30 scores 3 months before operation (P<0.05). No serious adverse reactions related to treatment were reported, and the application of analgesics was reduced. MRgFUS relieves bone metastasis pain in children with good curative effect and high safety.

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September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Wang, B., Li, J., & Wei, X. (2019). Short-term efficacy and safety of MR-guided focused ultrasound surgery for analgesia in children with metastatic bone tumors. Oncology Letters, 18, 3283-3289. https://doi.org/10.3892/ol.2019.10628
MLA
Wang, B., Li, J., Wei, X."Short-term efficacy and safety of MR-guided focused ultrasound surgery for analgesia in children with metastatic bone tumors". Oncology Letters 18.3 (2019): 3283-3289.
Chicago
Wang, B., Li, J., Wei, X."Short-term efficacy and safety of MR-guided focused ultrasound surgery for analgesia in children with metastatic bone tumors". Oncology Letters 18, no. 3 (2019): 3283-3289. https://doi.org/10.3892/ol.2019.10628