Open Access

High expression of CD47 in triple negative breast cancer is associated with epithelial‑mesenchymal transition and poor prognosis

  • Authors:
    • Jingping Yuan
    • Xuehui Shi
    • Chuang Chen
    • Huihua He
    • Lin Liu
    • Juan Wu
    • Honglin Yan
  • View Affiliations

  • Published online on: July 15, 2019     https://doi.org/10.3892/ol.2019.10618
  • Pages: 3249-3255
  • Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

CD47 functions as a dominant anti‑engulfment signal on tumour cells and is overexpressed in various malignant tumours. However, the expression and functional significance of CD47 in triple‑negative breast cancer (TNBC) is not completely understood. In the present study, CD47 was demonstrated to be overexpressed in TNBC solid tumours. Moreover, increased CD47 expression was significantly associated with an advanced tumour‑node‑metastasis stage, lymph node involvement and recurrence. Moreover, CD47 was an unfavourable and independent prognostic factor for 5‑year disease‑free survival in patients with TNBC. In addition, the expression of CD47 was associated with several markers of epithelial‑mesenchymal transition (EMT). The present study was the first to demonstrate an association between increased expression of CD47 with EMT and poor prognosis of TNBC. Thus, CD47 may be a potential prognostic biomarker and therapeutic target for TNBC.
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September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Yuan, J., Shi, X., Chen, C., He, H., Liu, L., Wu, J., & Yan, H. (2019). High expression of CD47 in triple negative breast cancer is associated with epithelial‑mesenchymal transition and poor prognosis. Oncology Letters, 18, 3249-3255. https://doi.org/10.3892/ol.2019.10618
MLA
Yuan, J., Shi, X., Chen, C., He, H., Liu, L., Wu, J., Yan, H."High expression of CD47 in triple negative breast cancer is associated with epithelial‑mesenchymal transition and poor prognosis". Oncology Letters 18.3 (2019): 3249-3255.
Chicago
Yuan, J., Shi, X., Chen, C., He, H., Liu, L., Wu, J., Yan, H."High expression of CD47 in triple negative breast cancer is associated with epithelial‑mesenchymal transition and poor prognosis". Oncology Letters 18, no. 3 (2019): 3249-3255. https://doi.org/10.3892/ol.2019.10618