Open Access

Identification of CD206 as a potential biomarker of cancer stem‑like cells and therapeutic agent in liver cancer

  • Authors:
    • Weimin Fan
    • Xue Yang
    • Fang Huang
    • Xiangmin Tong
    • Lifen Zhu
    • Shibing WangThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310000
  • View Affiliations

  • Published online on: July 26, 2019     https://doi.org/10.3892/ol.2019.10673
  • Pages: 3218-3226
  • Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The mannose receptor (CD206) functions in endocytosis and phagocytosis, and plays an important role in immune homeostasis. Tumor‑associated macrophages express high level of CD206 and are thought to contribute to cancer progression through tumor immunosuppression, metastasis and angiogenesis. However, the significance of CD206 in the pathology of liver cancer has not been investigated. The present study evaluated the clinical significance of CD206 in the progression and prognosis of liver cancer in pathological tissues from 327 patients. Increased CD206 expression was observed in liver cancer samples compared with healthy adjacent liver tissue (42.8 vs. 62.4%; P<0.05). CD206 expression was significantly associated with tumor size (P=0.009) and metastasis (P=0.041). The recurrence free survival rate of patients with CD206‑positive liver cancer was significantly decreased compared with patients with CD206‑negative liver cancer (P=0.003). A Cox regression model revealed that liver cancer survival was independently associated with tumor size, metastasis and α‑fetoprotein value. The results further revealed that CD206 expression in cancer stem cell (CSC)‑like cells was comparable to other internationally recognized biomarkers. Additionally, when CD206 expression was silenced in the liver cancer cell lines HepG2 and PLC/PRF/5 using a short hairpin RNA approach, migration and invasion of the cells significantly decreased compared with controls (P<0.01). CD206 expression in liver cancer significantly influences distant metastasis and spread, resulting in poor patient prognosis. Furthermore, CD206 may be a potential biomarker in CSC‑like cells to predict the occurrence of liver cancer.
View Figures
View References

Related Articles

Journal Cover

September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Fan, W., Yang, X., Huang, F., Tong, X., Zhu, L., & WangThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310000, S. (2019). Identification of CD206 as a potential biomarker of cancer stem‑like cells and therapeutic agent in liver cancer. Oncology Letters, 18, 3218-3226. https://doi.org/10.3892/ol.2019.10673
MLA
Fan, W., Yang, X., Huang, F., Tong, X., Zhu, L., WangThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310000, S."Identification of CD206 as a potential biomarker of cancer stem‑like cells and therapeutic agent in liver cancer". Oncology Letters 18.3 (2019): 3218-3226.
Chicago
Fan, W., Yang, X., Huang, F., Tong, X., Zhu, L., WangThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310000, S."Identification of CD206 as a potential biomarker of cancer stem‑like cells and therapeutic agent in liver cancer". Oncology Letters 18, no. 3 (2019): 3218-3226. https://doi.org/10.3892/ol.2019.10673