Open Access

The prognostic value of ADRA1 subfamily genes in gastric carcinoma

  • Authors:
    • Tingan Wang
    • Yuzhou Qin
    • Hao Lai
    • Weiyuan Wei
    • Zhao Li
    • Yang Yang
    • Mingwei Huang
    • Jiansi Chen
  • View Affiliations

  • Published online on: July 24, 2019     https://doi.org/10.3892/ol.2019.10660
  • Pages: 3150-3158
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Adrenergic receptor α1 (ADRA1) subfamily members, including ADRA1A, ADRA1B and ADRA1D, are understood to participate in cardiac disease and benign prostatic hyperplasia. In addition, adrenergic signals in cell pathways can promote the development of cancer. However, little is understood regarding the associations between ADRA1 subfamily members and gastric carcinoma (GC). The present study investigated the prognostic value of the ADRA1 subfamily genes in GC. Data from a total of 379 patients with GC were obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases. Kaplan‑Meier analysis and Cox regression analysis were used to determine associations with overall survival (OS) and to evaluate the median survival time using hazard ratios (HRs) and 95% confidence intervals (CIs). Multivariate survival analysis revealed that low expression levels of ADRA1A (HR, 0.595; 95% CI, 0.426‑0.831; adjusted P=0.002) ADRA1B (HR, 0.576; 95% CI, 0.412‑0.805; adjusted P=0.001) and ADRA1D (HR, 0.559; 95% CI, 0.398‑0.787; adjusted P=0.001) were associated with a favourable OS. Joint‑effects analysis demonstrated that combinations of low expression levels of ARDA1A, ARDA1B and ARDA1D were significantly associated with a favourable OS. Overall, the current results suggested that the mRNA expression levels of ARDA1 subfamily members may serve as potential prognostic markers for GC.

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September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Wang, T., Qin, Y., Lai, H., Wei, W., Li, Z., Yang, Y. ... Chen, J. (2019). The prognostic value of ADRA1 subfamily genes in gastric carcinoma. Oncology Letters, 18, 3150-3158. https://doi.org/10.3892/ol.2019.10660
MLA
Wang, T., Qin, Y., Lai, H., Wei, W., Li, Z., Yang, Y., Huang, M., Chen, J."The prognostic value of ADRA1 subfamily genes in gastric carcinoma". Oncology Letters 18.3 (2019): 3150-3158.
Chicago
Wang, T., Qin, Y., Lai, H., Wei, W., Li, Z., Yang, Y., Huang, M., Chen, J."The prognostic value of ADRA1 subfamily genes in gastric carcinoma". Oncology Letters 18, no. 3 (2019): 3150-3158. https://doi.org/10.3892/ol.2019.10660