Open Access

Significance of miR-27a and miR-31 in early diagnosis and prognosis of colorectal cancer

  • Authors:
    • Qingjun Cui
  • View Affiliations

  • Published online on: July 16, 2019     https://doi.org/10.3892/ol.2019.10621
  • Pages: 3092-3096
  • Copyright: © Cui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Clinical significance of micro-ribonucleic acid (miR)-27a and miR-31 in the early diagnosis and prognosis of colorectal cancer were investigated. Forty patients with colorectal malignancy admitted to Xintai People's Hospital from February 2014 to April 2018 were enrolled as the observation group, of which 30 patients were diagnosed via pathological biopsy. Another 40 patients diagnosed with colorectal polyp and receiving surgical treatment were selected as the control group. The relative amount of miR-27a and miR-31 was measured. The relative expression levels of miR-27a and miR-31 in patients were analyzed. The diagnostic sensitivity, specificity and accordance rates of positive miR-27a and miR-31 expression in colorectal cancer were recorded. The correlation of the relative expression levels of miR-27a and miR-31 with the survival time of patients were analyzed. In the observation group, the relative expression levels of miR-27a and miR-31 in patients with lymph node metastasis and distant metastasis were higher than those in patients without lymph node metastasis and distant metastasis (P<0.05). Histological type of patients with non-mucinous carcinoma had increased relative expression levels of miR-27a and miR-31 in comparison with those with mucinous carcinoma (P<0.05). In terms of Duke's grade, the relative expression levels of miR-27a and miR-31 in patients with grade C and D were higher than those in patients with grade A and B (P<0.05). The diagnostic sensitivity, specificity and accordance rate of positive miR-27a expression were lower than those of positive miR-31 expression. The relative expression levels of miR-27a and miR-31 were positively correlated with the survival time of patients (P<0.05). The expression levels of miR-27a and miR-31 are related to distant metastasis and tumor grade of patients with colorectal cancer, and positively associated with the survival time of patients, having high diagnostic value.

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September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Cui, Q. (2019). Significance of miR-27a and miR-31 in early diagnosis and prognosis of colorectal cancer. Oncology Letters, 18, 3092-3096. https://doi.org/10.3892/ol.2019.10621
MLA
Cui, Q."Significance of miR-27a and miR-31 in early diagnosis and prognosis of colorectal cancer". Oncology Letters 18.3 (2019): 3092-3096.
Chicago
Cui, Q."Significance of miR-27a and miR-31 in early diagnosis and prognosis of colorectal cancer". Oncology Letters 18, no. 3 (2019): 3092-3096. https://doi.org/10.3892/ol.2019.10621