Open Access

Prognostic value of chloride channel accessory mRNA expression in colon cancer

  • Authors:
    • Xiaohang Pan
    • Qiaoqi Wang
    • Chenfei Xu
    • Ling Yan
    • Sen Pang
    • Jialiang Gan
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  • Published online on: July 15, 2019     https://doi.org/10.3892/ol.2019.10615
  • Pages: 2967-2976
  • Copyright: © Pan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Chloride channel accessory (CLCA) is a gene family that encode Ca2+ activated chloride channels, which make a substantial contribution to various diseases. The aim of the present study was to investigate the prognostic value of CLCA expression in colon cancer. In an attempt to elucidate the value of CLCA mRNA expression in the prognosis of patients with colon cancer, the gene expression data of 438 patients with colon cancer were analyzed. The source of the data was The Cancer Genome Atlas, and it was identified that high expression levels of CLCA1 and CLCA2 were associated with a favorable overall survival (OS) time in patients with colon cancer. As revealed by joint effects analysis, the co‑occurrence of high expression levels of CLCA1 and CLCA2 was associated with a favorable OS time in patients with colon cancer. CLCA genes were investigated using gene set enrichment analysis. The results of the bioinformatics analysis demonstrated that high expression levels of CLCA1 and CLCA2 were associated with the prognosis of colon cancer. These findings suggest that CLCA1 and CLCA2 are potential prognostic biomarkers for patients with colon cancer. Furthermore, combining CLCA1 and CLCA2 can enhance the sensitivity of the prediction of the OS time of patients with colon cancer.
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September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Pan, X., Wang, Q., Xu, C., Yan, L., Pang, S., & Gan, J. (2019). Prognostic value of chloride channel accessory mRNA expression in colon cancer. Oncology Letters, 18, 2967-2976. https://doi.org/10.3892/ol.2019.10615
MLA
Pan, X., Wang, Q., Xu, C., Yan, L., Pang, S., Gan, J."Prognostic value of chloride channel accessory mRNA expression in colon cancer". Oncology Letters 18.3 (2019): 2967-2976.
Chicago
Pan, X., Wang, Q., Xu, C., Yan, L., Pang, S., Gan, J."Prognostic value of chloride channel accessory mRNA expression in colon cancer". Oncology Letters 18, no. 3 (2019): 2967-2976. https://doi.org/10.3892/ol.2019.10615