Open Access

Estrogen receptor 1 mutations in 260 cervical cancer samples from Chinese patients

  • Authors:
    • Xin‑Min Yang
    • Zhi‑Min Wu
    • Huang Huang
    • Xiao‑Yan Chu
    • Jun Lou
    • Li‑Xian Xu
    • Yuan‑Ting Chen
    • Li‑Qun Wang
    • Ou‑Ping Huang
  • View Affiliations

  • Published online on: July 15, 2019     https://doi.org/10.3892/ol.2019.10612
  • Pages: 2771-2776
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical cancer is one of the leading causes of cancer‑associated mortality among females; however, the underlying molecular mechanisms of its carcinogenesis remain largely unclear. Previous comprehensive genomic studies have revealed prevalent estrogen receptor 1 (ESR1) mutations in breast cancer, which are rare in certain other types of cancer. To the best of our knowledge, it is unknown whether ESR1 mutations also exist in cervical cancer. Considering the evidence that cervical cancer shares certain genetic aberrations with breast cancer, and that the progression of both breast and cervical cancers can be affected by estrogen, it is possible that cervical cancer may also harbor ESR1 mutations. In the present study, a total of 260 Chinese cervical cancer samples with distinct subtypes were tested for the presence of ESR1 mutations. A total of three heterozygous missense ESR1 mutations, p.K303R (c.908A>G), p.T311M (c.932C>T) and p.Y537C (c.1610A>G), were identified in 3/207 (1.4%) cervical squamous cell carcinoma samples, which were absent in 27 adenosquamous carcinomas and 26 adenocarcinomas samples. Of the three individuals with an ESR1mutation, 1 patient was also diagnosed with ovarian endometriosis and the other 2 patients were diagnosed with a uterine fibroid. A bioinformatics analysis suggested that these ESR1 mutations may be pathogenic by promoting the development of cervical cancer. Furthermore, a previous comprehensive study confirmed that individuals with cervical squamous cell carcinoma possessed ESR1 mutations. These combined studies indicate that ESR1 mutations may participate in the carcinogenesis of cervical squamous cell carcinoma, albeit at a low frequency. In conclusion, the present study identified three potentially pathogenic ESR1 mutations in Chinese cervical squamous cell carcinoma samples, but not in other subtypes.

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September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Yang, X., Wu, Z., Huang, H., Chu, X., Lou, J., Xu, L. ... Huang, O. (2019). Estrogen receptor 1 mutations in 260 cervical cancer samples from Chinese patients. Oncology Letters, 18, 2771-2776. https://doi.org/10.3892/ol.2019.10612
MLA
Yang, X., Wu, Z., Huang, H., Chu, X., Lou, J., Xu, L., Chen, Y., Wang, L., Huang, O."Estrogen receptor 1 mutations in 260 cervical cancer samples from Chinese patients". Oncology Letters 18.3 (2019): 2771-2776.
Chicago
Yang, X., Wu, Z., Huang, H., Chu, X., Lou, J., Xu, L., Chen, Y., Wang, L., Huang, O."Estrogen receptor 1 mutations in 260 cervical cancer samples from Chinese patients". Oncology Letters 18, no. 3 (2019): 2771-2776. https://doi.org/10.3892/ol.2019.10612