Open Access

Notch and breast cancer metastasis: Current knowledge, new sights and targeted therapy (Review)

  • Authors:
    • Yu Zhang
    • Zi‑Yan Xie
    • Xuan‑Tong Guo
    • Xing‑Hua Xiao
    • Li‑Xia Xiong
  • View Affiliations

  • Published online on: July 22, 2019     https://doi.org/10.3892/ol.2019.10653
  • Pages: 2743-2755
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer is the most common type of invasive cancer in females and metastasis is one of the major causes of breast cancer‑associated mortality. Following detachment from the primary site, disseminated tumor cells (DTCs) enter the bloodstream and establish secondary colonies during the metastatic process. An increasing amount of studies have elucidated the importance of Notch signaling in breast cancer metastasis; therefore, the present review focuses on the mechanisms by which Notch contributes to the occurrence of breast cancer DTCs, increases their motility, establishes interactions with the tumor microenvironment, protects DTCs from host surveillance and finally facilitates secondary colonization. Identification of the underlying mechanisms of Notch‑associated breast cancer metastasis will provide additional insights that may contribute towards the development of novel Notch‑targeted therapeutic strategies, which may aid in reducing metastasis, culminating in an improved patient prognosis.
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Journal Cover

September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Zhang, Y., Xie, Z., Guo, X., Xiao, X., & Xiong, L. (2019). Notch and breast cancer metastasis: Current knowledge, new sights and targeted therapy (Review). Oncology Letters, 18, 2743-2755. https://doi.org/10.3892/ol.2019.10653
MLA
Zhang, Y., Xie, Z., Guo, X., Xiao, X., Xiong, L."Notch and breast cancer metastasis: Current knowledge, new sights and targeted therapy (Review)". Oncology Letters 18.3 (2019): 2743-2755.
Chicago
Zhang, Y., Xie, Z., Guo, X., Xiao, X., Xiong, L."Notch and breast cancer metastasis: Current knowledge, new sights and targeted therapy (Review)". Oncology Letters 18, no. 3 (2019): 2743-2755. https://doi.org/10.3892/ol.2019.10653