Open Access

Expression of programmed cell death‑ligand 1 in primary testicular diffuse large B cell lymphoma: A retrospective study

  • Authors:
    • Dongdong Zhu
    • Jun Zhu
    • Wei Yu
    • Peng Hong
    • Yu Fan
    • Zhongyuan Zhang
    • Jun Li
    • Qun He
    • Wenke Han
    • Cheng Shen
    • Jie Jin
  • View Affiliations

  • Published online on: July 9, 2019     https://doi.org/10.3892/ol.2019.10595
  • Pages: 2670-2676
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study evaluated programmed cell death‑ligand 1 (PD‑L1) expression in tumor cells and in the tumor microenvironment (TME) and its association with clinical data in primary testicular diffuse large B cell lymphoma (DLBCL). PD‑L1 was determined by immunohistochemistry in 30 patients with primary testicular DLBCL and assessed for associations with clinical characteristics, progression‑free survival (PFS) and overall survival (OS). The mean patient age was 62.2 years. Overall, 10 (33.3%) patients had advanced‑stage (stage III/IV) disease and 14 (46.7%) patients had an International Prognostic Index (IPI) of ≥3. The median follow‑up time following orchiectomy was 23.5 months. During this time, 10 (33.3%) patients experienced disease progression and 11 (36.7%) patients succumbed. PD‑L1 expression in tumor cells and in the TME was detected in 20 (66.7%) and 13 (43.3%) patients, respectively. PD‑L1 expression on tumor cells and in the TME was higher in those at an early stage compared with patients with an advanced stage of disease (P=0.045 and 0.017, respectively). In addition, PD‑L1 expression in tumor cells was higher in patients with a low IPI compared with those with a high IPI (P=0.019). A Kaplan‑Meier analysis identified no association of PD‑L1 expression on tumor cells with PFS (P=0.763) or OS (P=0.531), or of PD‑L1 expression in the TME with PFS (P=0.572) or OS (P=0.934). The present study demonstrated that PD‑L1 expression in tumor cells and in the TME was higher in patients at an early stage of disease compared with those at an advanced stage, and that PD‑L1 expression on tumor cells was higher in patients with a low IPI than in those with a high IPI. Furthermore, PD‑L1 expression in tumor cells and in the TME was not associated with PFS or OS.
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September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Zhu, D., Zhu, J., Yu, W., Hong, P., Fan, Y., Zhang, Z. ... Jin, J. (2019). Expression of programmed cell death‑ligand 1 in primary testicular diffuse large B cell lymphoma: A retrospective study. Oncology Letters, 18, 2670-2676. https://doi.org/10.3892/ol.2019.10595
MLA
Zhu, D., Zhu, J., Yu, W., Hong, P., Fan, Y., Zhang, Z., Li, J., He, Q., Han, W., Shen, C., Jin, J."Expression of programmed cell death‑ligand 1 in primary testicular diffuse large B cell lymphoma: A retrospective study". Oncology Letters 18.3 (2019): 2670-2676.
Chicago
Zhu, D., Zhu, J., Yu, W., Hong, P., Fan, Y., Zhang, Z., Li, J., He, Q., Han, W., Shen, C., Jin, J."Expression of programmed cell death‑ligand 1 in primary testicular diffuse large B cell lymphoma: A retrospective study". Oncology Letters 18, no. 3 (2019): 2670-2676. https://doi.org/10.3892/ol.2019.10595