Open Access

Expression patterns of programmed death‑1 and programmed death‑1 ligand‑1 on T cells in gastric cancer

  • Authors:
    • Ji‑Hyun Kim1 Kim
    • Shinn‑Young Kim
    • Eun‑Young Shin
    • Ji‑Han Jung
    • Hyun‑Joo Choi
    • Kyong‑Hwa Jun
  • View Affiliations

  • Published online on: July 9, 2019     https://doi.org/10.3892/ol.2019.10594
  • Pages: 2661-2669
  • Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to evaluate programmed death‑1 (PD‑1) and programmed death‑1 ligand‑1 (PD‑L1) expression in gastric carcinoma and to assess their effect on survival rate. A total of 170 surgically resected specimens were obtained from patients diagnosed with gastric carcinoma at St. Vincent's Hospital, The Catholic University of Korea. Paraffin tissue sections from tissue microarray blocks were subjected to immunohistochemical analysis of PD‑1 and PD‑L1. In addition, PD‑1 expression on CD4+ and CD8+ T cells isolated from peripheral blood mononuclear cells and gastric cancer tissues was evaluated by multicolor flow cytometry. PD‑1 and PD‑L1 were expressed in 30.0 and 60.5% of the gastric cancer tissues, respectively. The expression of PD‑L1 was higher in patients with advanced T (P=0.035) and Tumor, Node and Metastasis stage (P=0.05). The patients with positive PD‑L1 expression had shorter disease‑free survival time than those without PD‑L1 expression (P=0.005). Additionally, PD‑L1 expression was significantly associated with poor prognosis (P=0.015). PD‑1 and PD‑L1 expression levels were significantly higher on CD8+ T cells than on CD4+ T cells (P<0.001). The data of the present study suggested that PD‑L1 expression may be an independent indicator of poor prognosis in patients with gastric cancer. Furthermore, PD‑L1 expression may play a role in immune evasion of gastric cancer.
View Figures
View References

Related Articles

Journal Cover

September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Kim, J., Kim, S., Shin, E., Jung, J., Choi, H., & Jun, K. (2019). Expression patterns of programmed death‑1 and programmed death‑1 ligand‑1 on T cells in gastric cancer. Oncology Letters, 18, 2661-2669. https://doi.org/10.3892/ol.2019.10594
MLA
Kim, J., Kim, S., Shin, E., Jung, J., Choi, H., Jun, K."Expression patterns of programmed death‑1 and programmed death‑1 ligand‑1 on T cells in gastric cancer". Oncology Letters 18.3 (2019): 2661-2669.
Chicago
Kim, J., Kim, S., Shin, E., Jung, J., Choi, H., Jun, K."Expression patterns of programmed death‑1 and programmed death‑1 ligand‑1 on T cells in gastric cancer". Oncology Letters 18, no. 3 (2019): 2661-2669. https://doi.org/10.3892/ol.2019.10594