Cryptotanshinone inhibits lung cancer invasion via microRNA‑133a/matrix metalloproteinase 14 regulation

  • Authors:
    • Huijuan Wang
    • Yanshan Zhang
    • Yingguo Zhang
    • Wenling Liu
    • Jihong Wang
  • View Affiliations

  • Published online on: July 5, 2019     https://doi.org/10.3892/ol.2019.10580
  • Pages: 2554-2559
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Abstract

Cryptotanshinone inhibits the proliferative and colony formation abilities of human non‑small cell lung cancer cells (NSCLCs). The present study reported that signal transducer and activator of transcription 3 is not the only target of cryptotanshinone during the inhibition of human NSCLCs. It was identified that cryptotanshinone upregulates the expression levels of microRNA (miR)‑30d‑5p, miR‑126‑3p, miR‑133a, miR‑338‑3p and miR‑451a, and downregulates miR‑21‑5p, miR‑96‑5p, miR‑182‑5p and miR‑205‑5p. Among these, miR‑133a was the most significantly upregulated. miR‑133a targets and downregulates the expression of matrix metalloproteinase (MMP)14; however, MMP15, MMP16 and MMP24 were determined to be unaffected. This process was identified to be independent of tissue inhibitor of metalloproteinases 2. Cryptotanshinone also suppresses the invasion of human NSCLCs, which may be due to the inhibited expression of MMP14. In conclusion, cryptotanshinone may serve as a potential therapeutic agent in the treatment of lung cancer.

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September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Wang, H., Zhang, Y., Zhang, Y., Liu, W., & Wang, J. (2019). Cryptotanshinone inhibits lung cancer invasion via microRNA‑133a/matrix metalloproteinase 14 regulation. Oncology Letters, 18, 2554-2559. https://doi.org/10.3892/ol.2019.10580
MLA
Wang, H., Zhang, Y., Zhang, Y., Liu, W., Wang, J."Cryptotanshinone inhibits lung cancer invasion via microRNA‑133a/matrix metalloproteinase 14 regulation". Oncology Letters 18.3 (2019): 2554-2559.
Chicago
Wang, H., Zhang, Y., Zhang, Y., Liu, W., Wang, J."Cryptotanshinone inhibits lung cancer invasion via microRNA‑133a/matrix metalloproteinase 14 regulation". Oncology Letters 18, no. 3 (2019): 2554-2559. https://doi.org/10.3892/ol.2019.10580