Open Access

Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression

  • Authors:
    • Feixue Xu
    • Xiaoqiang Si
    • Jingran Du
    • Feihua Xu
    • Aihong Yang
    • Caixia Zhang
    • Xiucai Zhang
    • Yongxiu Yang
  • View Affiliations

  • Published online on: June 28, 2019     https://doi.org/10.3892/ol.2019.10542
  • Pages: 2477-2483
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Synaptic cell adhesion molecules (SynCAMs) are single transmembrane proteins that belong to the immunoglobulin superfamily of cell adhesion molecules. In the present study, a decrease in SynCAM levels in ovarian tumor tissues compared with normal tissues is reported; the downregulation was accompanied by the grade malignancy. The observations suggested that SynCAM may be essential for important novel functions in ovarian cancer. Further experiments showed that low SynCAM expression inhibited membrane palmitoylated protein 6 (MPP6) expression, a member of the palmitoylated membrane protein subfamily of peripheral membrane‑associated guanylate kinases. In addition, low levels of MPP6 in ovarian tumor tissues correlated with shorter patient survival. A SynCAM‑regulated pathway may provide molecular targets for the treatment of ovarian cancer and novel biomarkers to be used in clinical diagnosis.

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September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Xu, F., Si, X., Du, J., Xu, F., Yang, A., Zhang, C. ... Yang, Y. (2019). Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression. Oncology Letters, 18, 2477-2483. https://doi.org/10.3892/ol.2019.10542
MLA
Xu, F., Si, X., Du, J., Xu, F., Yang, A., Zhang, C., Zhang, X., Yang, Y."Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression". Oncology Letters 18.3 (2019): 2477-2483.
Chicago
Xu, F., Si, X., Du, J., Xu, F., Yang, A., Zhang, C., Zhang, X., Yang, Y."Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression". Oncology Letters 18, no. 3 (2019): 2477-2483. https://doi.org/10.3892/ol.2019.10542