Open Access

Overexpression of lncRNA GATA6‑AS inhibits cancer cell proliferation in mantle cell lymphoma by downregulating GLUT1

  • Authors:
    • Zhenwei Fan
    • Xuan Wang
    • Peng Li
    • Chunli Mei
    • Min Zhang
    • Chunshan Zhao
  • View Affiliations

  • Published online on: June 28, 2019     https://doi.org/10.3892/ol.2019.10540
  • Pages: 2443-2447
  • Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Long non‑coding RNA GATA6 antisense RNA 1 (lncRNA GATA6‑AS) is a recently identified lncRNA that is involved in endothelial‑mesenchymal transition. The present study aimed to investigate the involvement of GATA6‑AS in the progression of mantle cell lymphoma (MCL). It was found that plasma lncRNA GATA6‑AS expression level was downregulated in patients with MCL, compared with that in healthy controls. Downregulation of lncRNA GATA6‑AS has potential diagnostic value in early stage MCL. Overexpression of lncRNA GATA6‑AS resulted in inhibited glucose uptake in the human cell lines JVM‑2 and Z‑138 MCL. Inhibited expression of glucose transporter 1 (GLUT1) was observed in MCL cells following lncRNA GATA6‑AS overexpression, whilst GLUT1 overexpression did not alter the expression of lncRNA GATA6‑AS. Additionally, lncRNA GATA6‑AS overexpression inhibited, whilst GLUT1 overexpression promoted the proliferation of JVM‑2 and Z‑138 MCL cells; GLUT1 overexpression partially reversed the inhibitory effects of lncRNA GATA6‑AS overexpression. It was therefore concluded that lncRNA GATA6‑AS may inhibit cancer cell proliferation in MCL by downregulating GLUT1.

Related Articles

Journal Cover

September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Fan, Z., Wang, X., Li, P., Mei, C., Zhang, M., & Zhao, C. (2019). Overexpression of lncRNA GATA6‑AS inhibits cancer cell proliferation in mantle cell lymphoma by downregulating GLUT1. Oncology Letters, 18, 2443-2447. https://doi.org/10.3892/ol.2019.10540
MLA
Fan, Z., Wang, X., Li, P., Mei, C., Zhang, M., Zhao, C."Overexpression of lncRNA GATA6‑AS inhibits cancer cell proliferation in mantle cell lymphoma by downregulating GLUT1". Oncology Letters 18.3 (2019): 2443-2447.
Chicago
Fan, Z., Wang, X., Li, P., Mei, C., Zhang, M., Zhao, C."Overexpression of lncRNA GATA6‑AS inhibits cancer cell proliferation in mantle cell lymphoma by downregulating GLUT1". Oncology Letters 18, no. 3 (2019): 2443-2447. https://doi.org/10.3892/ol.2019.10540