Open Access

Mitofusin 2 inhibits bladder cancer cell proliferation and invasion via the Wnt/β‑catenin pathway

  • Authors:
    • Guofu Pang
    • Qun Xie
    • Juanjuan Yao
  • View Affiliations

  • Published online on: July 5, 2019     https://doi.org/10.3892/ol.2019.10570
  • Pages: 2434-2442
  • Copyright: © Pang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate the biological role of the mitochondrial GTPase mitofusin‑2 (MFN2) in bladder cancer. MFN2 mRNA expression in tumor and paired adjacent non‑tumor tissues from 8 patients was investigated using reverse transcription‑quantitative polymerase chain reaction analysis. Immunohistochemistry was used to investigate MFN2 expression in 117 bladder cancer specimens. The associations of MFN2 expression with clinicopathological parameters were evaluated statistically. In addition, the biological role of MFN2 in the proliferation, migration and invasion of bladder cancer cells was examined. It was identified that MFN2 expression was significantly downregulated in bladder cancer tissues compared with normal tissues. MFN2 expression was associated with tumor stage, tumor grade and lymph node status. Furthermore, patients with low MFN2 expression demonstrated a shorter overall survival time (P=0.025). MFN2 knockdown by small interfering RNA promoted cancer cell proliferation, migration and invasion in vitro, and enhanced tumor progression in vivo. Mechanistically, MFN2 was revealed to be involved in Wnt/β‑catenin signaling. In conclusion, MFN2 may serve as a potential therapeutic target in the treatment of bladder cancer, and the progress of bladder cancer may be delayed by regulating MFN2 expression.

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September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Pang, G., Xie, Q., & Yao, J. (2019). Mitofusin 2 inhibits bladder cancer cell proliferation and invasion via the Wnt/β‑catenin pathway. Oncology Letters, 18, 2434-2442. https://doi.org/10.3892/ol.2019.10570
MLA
Pang, G., Xie, Q., Yao, J."Mitofusin 2 inhibits bladder cancer cell proliferation and invasion via the Wnt/β‑catenin pathway". Oncology Letters 18.3 (2019): 2434-2442.
Chicago
Pang, G., Xie, Q., Yao, J."Mitofusin 2 inhibits bladder cancer cell proliferation and invasion via the Wnt/β‑catenin pathway". Oncology Letters 18, no. 3 (2019): 2434-2442. https://doi.org/10.3892/ol.2019.10570