Open Access

Impact of microRNA‑29b on natural killer cells in T‑cell acute lymphoblastic leukemia

  • Authors:
    • Fengyan Jin
    • Zhonghua Du
    • Yang Tang
    • Lixia Wang
    • Yanping Yang
  • View Affiliations

  • Published online on: July 4, 2019     https://doi.org/10.3892/ol.2019.10559
  • Pages: 2394-2403
  • Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Natural killer (NK)‑based immunotherapeutic strategies are showing promise in the clinic, particularly against acute myeloid leukemia (AML). Similar treatments for T‑cell acute lymphoblastic leukemia (T‑ALL) have been less successful, which is due to the higher resistance of T‑ALL blasts to the cytotoxic function of NK cells. Herein, microRNA‑29b (miR‑29b) upregulation was identified in NK cells in both neurogenic locus notch homolog protein 1 (Notch1)‑T‑ALL mice and patients with T‑ALL. Furthermore, miR‑29b expression levels were downregulated in T‑ALL blast cells. In addition, there was a selective downregulation of an immature subset of NK cells, as well as a reduction in interferon γ (IFNγ) production and natural killer receptor group 2, member D (NKG2D) expression level by NK cells in Notch1‑T‑ALL mice and patients with T‑ALL. Furthermore, when miR‑29b knock‑out NK cells were adoptively transfused into Notch1‑T‑ALL mice, partial restoration of IFNγ production and NKG2D expression was observed in NK cells, accompanied by retarded ALL progression and improved survival time. These results implied that T‑ALL blast immune evasion occurred via miR‑29b‑mediated dysregulation in NK cells in the T‑ALL microenvironment.

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September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Jin, F., Du, Z., Tang, Y., Wang, L., & Yang, Y. (2019). Impact of microRNA‑29b on natural killer cells in T‑cell acute lymphoblastic leukemia. Oncology Letters, 18, 2394-2403. https://doi.org/10.3892/ol.2019.10559
MLA
Jin, F., Du, Z., Tang, Y., Wang, L., Yang, Y."Impact of microRNA‑29b on natural killer cells in T‑cell acute lymphoblastic leukemia". Oncology Letters 18.3 (2019): 2394-2403.
Chicago
Jin, F., Du, Z., Tang, Y., Wang, L., Yang, Y."Impact of microRNA‑29b on natural killer cells in T‑cell acute lymphoblastic leukemia". Oncology Letters 18, no. 3 (2019): 2394-2403. https://doi.org/10.3892/ol.2019.10559