Open Access

Expression of septin 2 and association with clinicopathological parameters in colorectal cancer

  • Authors:
    • Haoyu He
    • Junjun Li
    • Meng Xu
    • Ziliang Kan
    • Yang Gao
    • Caijun Yuan
  • View Affiliations

  • Published online on: June 26, 2019     https://doi.org/10.3892/ol.2019.10528
  • Pages: 2376-2383
  • Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Septin 2 (SEPT2) is a tumor‑related gene belonging to the SEPT family that affects the cellular processes of hepatoma carcinoma cells, glioblastoma cells and mesangial cells and is highly expressed in breast cancer, biliary tract cancer and acute myeloid leukemia. Colorectal cancer (CRC) is the third most common type of malignancy in humans. In the present study, Oncomine database was used to compare the expression pattern of SEPT2 mRNA between CRC and normal tissues. Additionally, protein expression in 90 pairs of CRC and paracancerous tissues was analyzed by western blotting and immunohistochemistry (IHC). The results showed that SEPT2 was highly expressed in CRC tissues at the mRNA and protein levels. SEPT2 expression quantified by IHC was associated with lymph node metastasis, the degree of differentiation and TNM staging. Increased SEPT2 wass associated with reduced overall survival (OS) according to Kaplan‑Meier analysis. COX proportional hazard analysis indicated that SEPT2 was an independent factor that influenced the OS of patients with CRC. Therefore, SEPT2 was associated with the occurrence, progression and prognosis of CRC and thus, may be a marker and prognostic indicator of CRC.

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September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
He, H., Li, J., Xu, M., Kan, Z., Gao, Y., & Yuan, C. (2019). Expression of septin 2 and association with clinicopathological parameters in colorectal cancer. Oncology Letters, 18, 2376-2383. https://doi.org/10.3892/ol.2019.10528
MLA
He, H., Li, J., Xu, M., Kan, Z., Gao, Y., Yuan, C."Expression of septin 2 and association with clinicopathological parameters in colorectal cancer". Oncology Letters 18.3 (2019): 2376-2383.
Chicago
He, H., Li, J., Xu, M., Kan, Z., Gao, Y., Yuan, C."Expression of septin 2 and association with clinicopathological parameters in colorectal cancer". Oncology Letters 18, no. 3 (2019): 2376-2383. https://doi.org/10.3892/ol.2019.10528