Open Access

Construction of subtype‑specific prognostic gene signatures for early‑stage non‑small cell lung cancer using meta feature selection methods

  • Authors:
    • Chunshui Liu
    • Linlin Wang
    • Tianjiao Wang
    • Suyan Tian
  • View Affiliations

  • Published online on: July 4, 2019     https://doi.org/10.3892/ol.2019.10563
  • Pages: 2366-2375
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Feature selection in the framework of meta‑analyses (meta feature selection), combines meta‑analysis with a feature selection process and thus allows meta‑analysis feature selection across multiple datasets. In the present study, a meta feature selection procedure that fitted a multiple Cox regression model to estimate the effect size of a gene in individual studies and to identify the overall effect of the gene using a meta‑analysis model was proposed. The method was used to identify prognostic gene signatures for lung adenocarcinoma and lung squamous cell carcinoma. Furthermore, redundant gene elimination (RGE) is of crucial importance during feature selection, and is also essential for a meta feature selection process. The current study demonstrated that the proposed meta feature selection procedure with RGE outperforms that without RGE in terms of predictive ability, model parsimony and biological interpretation.
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September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Liu, C., Wang, L., Wang, T., & Tian, S. (2019). Construction of subtype‑specific prognostic gene signatures for early‑stage non‑small cell lung cancer using meta feature selection methods. Oncology Letters, 18, 2366-2375. https://doi.org/10.3892/ol.2019.10563
MLA
Liu, C., Wang, L., Wang, T., Tian, S."Construction of subtype‑specific prognostic gene signatures for early‑stage non‑small cell lung cancer using meta feature selection methods". Oncology Letters 18.3 (2019): 2366-2375.
Chicago
Liu, C., Wang, L., Wang, T., Tian, S."Construction of subtype‑specific prognostic gene signatures for early‑stage non‑small cell lung cancer using meta feature selection methods". Oncology Letters 18, no. 3 (2019): 2366-2375. https://doi.org/10.3892/ol.2019.10563