Open Access

5‑Hydroxymethylcytosine as a potential epigenetic biomarker in papillary thyroid carcinoma

  • Authors:
    • Mengying Tong
    • Shuhang Gao
    • Wenjing Qi
    • Chang Shi
    • Meng Qiu
    • Fang Yang
    • Shanshan Bai
    • Husha Li
    • Zhizhou Wang
    • Zhigang Sun
    • Lina Wang
    • Ying Che
  • View Affiliations

  • Published online on: June 27, 2019     https://doi.org/10.3892/ol.2019.10531
  • Pages: 2304-2309
  • Copyright: © Tong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

DNA methylation at the 5 position of cytosine (5‑mC) is an epigenetic hallmark that is critical in various biological and pathological processes such as DNA methylation regulation, and initiation and development of cancers. 5‑mC can be oxidized to 5‑hydroxymethylcytosine (5‑hmC) by the ten‑eleven translocation family of DNA hydroxylases. Accumulating evidence has reported that loss of 5‑hmC is associated with cancer development. However, its level in papillary thyroid carcinoma (PTC) remains unclear. The present study reports that the loss of 5‑hmC is an epigenetic mark of PTCs, associated with their malignant biological behavior, providing diagnostic and predictive advantages over DNA hypomethylation (5‑mC), an acknowledged epigenetic alteration in cancer. In addition, the 5‑hmC staining levels were decreased in cases of micro‑carcinoma with lymph node metastasis, which suggests that 5‑hmC expression levels could be used as valuable biomarkers for predicting malignant potential and assist in the selection of therapeutic strategies in PTC; therefore, 5‑hmC has the potential to provide a more precise direction for PTC therapy.

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September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Tong, M., Gao, S., Qi, W., Shi, C., Qiu, M., Yang, F. ... Che, Y. (2019). 5‑Hydroxymethylcytosine as a potential epigenetic biomarker in papillary thyroid carcinoma. Oncology Letters, 18, 2304-2309. https://doi.org/10.3892/ol.2019.10531
MLA
Tong, M., Gao, S., Qi, W., Shi, C., Qiu, M., Yang, F., Bai, S., Li, H., Wang, Z., Sun, Z., Wang, L., Che, Y."5‑Hydroxymethylcytosine as a potential epigenetic biomarker in papillary thyroid carcinoma". Oncology Letters 18.3 (2019): 2304-2309.
Chicago
Tong, M., Gao, S., Qi, W., Shi, C., Qiu, M., Yang, F., Bai, S., Li, H., Wang, Z., Sun, Z., Wang, L., Che, Y."5‑Hydroxymethylcytosine as a potential epigenetic biomarker in papillary thyroid carcinoma". Oncology Letters 18, no. 3 (2019): 2304-2309. https://doi.org/10.3892/ol.2019.10531