Open Access

The true colors of autophagy in doxorubicin‑induced cardiotoxicity (Review)

  • Authors:
    • Bin Xiao
    • Lang Hong
    • Xinyong Cai
    • Songbo Mei
    • Ping Zhang
    • Liang Shao
  • View Affiliations

  • Published online on: July 5, 2019     https://doi.org/10.3892/ol.2019.10576
  • Pages: 2165-2172
  • Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

Patients with cancer receiving doxorubicin‑based chemotherapy often have to stop taking the drug due to its cardiotoxicity and therefore lose out on the beneficial effects of its potent antitumor activity. Doxorubicin has been demonstrated to damage cardiomyocytes via various mechanisms, including accumulation of reactive oxygen species (ROS), DNA damage and autophagy dysfunction. The present review focuses on autophagy, describing the general process of autophagy and the controversy surrounding its role in doxorubicin‑induced cardiotoxicity. In addition, the associations between autophagy and apoptosis, ROS, DNA damage and inflammatory processes are discussed. In the future, it will be useful to further elucidate the process of autophagy and reveal its association with various pathological processes to develop effective strategies of preventing doxorubicin‑induced cardiotoxicity.
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September 2019
Volume 18 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Xiao, B., Hong, L., Cai, X., Mei, S., Zhang, P., & Shao, L. (2019). The true colors of autophagy in doxorubicin‑induced cardiotoxicity (Review). Oncology Letters, 18, 2165-2172. https://doi.org/10.3892/ol.2019.10576
MLA
Xiao, B., Hong, L., Cai, X., Mei, S., Zhang, P., Shao, L."The true colors of autophagy in doxorubicin‑induced cardiotoxicity (Review)". Oncology Letters 18.3 (2019): 2165-2172.
Chicago
Xiao, B., Hong, L., Cai, X., Mei, S., Zhang, P., Shao, L."The true colors of autophagy in doxorubicin‑induced cardiotoxicity (Review)". Oncology Letters 18, no. 3 (2019): 2165-2172. https://doi.org/10.3892/ol.2019.10576