Liver metastases from maxillary sinus sinonasal undifferentiated carcinoma: A case report

  • Authors:
    • Vittorio D'Aguanno
    • Massimo Ralli
    • Bruna Cerbelli
    • Antonio Greco
    • Marco de Vincentiis
  • View Affiliations

  • Published online on: April 15, 2019     https://doi.org/10.3892/ol.2019.10251
  • Pages: 5811-5814
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Sinonasal undifferentiated carcinoma (SNUC) is a rare malignancy arising from the nasal cavity with neuroendocrine differentiation and aggressive behavior. When first diagnosed, SNUC is often locally advanced with nodal and distant metastases. The present study indicates a rare case of sole metastases to the liver from maxillary sinus undifferentiated carcinoma. Diagnosis was confirmed by total body computed tomography and immunohistochemical analysis on tissues from both maxillary and liver neoplastic tissues. SNUC is an aggressive malignancy characterized by a poor prognosis. Distant metastases commonly involve bones and lungs and should always be suspected in patients with locally advanced stages. Distant metastases can be found in unexpected organs due to dissemination via collateral venous plexuses; isolated liver metastatic disease may also occur. Although SNUC is considered a chemo‑sensitive malignancy, chemotherapy for metastatic SNUC needs to be further explored.

References

1 

Mitchell EH, Diaz A, Yilmaz T, Roberts D, Levine N, DeMonte F, Hanna EY and Kupferman ME: Multimodality treatment for sinonasal neuroendocrine carcinoma. Head Neck. 34:1372–1376. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Mendenhall WM, Mendenhall CM, Riggs CE Jr, Villaret DB and Mendenhall NP: Sinonasal undifferentiated carcinoma. Am J Clin Oncol. 29:27–31. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Musy PY, Reibel JF and Levine PA: Sinonasal undifferentiated carcinoma: The search for a better outcome. Laryngoscope. 112:1450–1455. 2002. View Article : Google Scholar : PubMed/NCBI

4 

van der Laan TP, Iepsma R, Witjes MJ, van der Laan BF, Plaat BE and Halmos GB: Meta-analysis of 701 published cases of sinonasal neuroendocrine carcinoma: The importance of differentiation grade in determining treatment strategy. Oral Oncol. 63:1–9. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Frierson HF Jr, Mills SE, Fechner RE, Taxy JB and Levine PA: Sinonasal undifferentiated carcinoma. An aggressive neoplasm derived from schneiderian epithelium and distinct from olfactory neuroblastoma. Am J Surg Pathol. 10:771–779. 1986. View Article : Google Scholar : PubMed/NCBI

6 

Morand GB, Anderegg N, Vital D, Ikenberg K, Huber GF, Soyka MB, Egger M and Holzmann D: Outcome by treatment modality in sinonasal undifferentiated carcinoma (SNUC): A case-series, systematic review and meta-analysis. Oral Oncol. 75:8–34. 2017. View Article : Google Scholar : PubMed/NCBI

7 

van der Laan TP, Bij HP, van Hemel BM, Plaat BE, Wedman J, van der Laan BF and Halmos GB: The importance of multimodality therapy in the treatment of sinonasal neuroendocrine carcinoma. Eur Arch Otorhinolaryngol. 270:2565–2568. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Rosenthal DI, Barker JL Jr, El-Naggar AK, Glisson BS, Kies MS, Diaz EM Jr, Clayman GL, Demonte F, Selek U, Morrison WH, et al: Sinonasal malignancies with neuroendocrine differentiation: Patterns of failure according to histologic phenotype. Cancer. 101:2567–2573. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Castelnuovo P, Turri-Zanoni M, Battaglia P, Antognoni P, Bossi P and Locatelli D: Sinonasal malignancies of anterior skull base: Histology-driven treatment strategies. Otolaryngol Clin North Am. 49:183–200. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Caselhos S, Ferreira C, Jácome M and Monteiro E: Liver metastasis of ethmoid sinus adenocarcinoma. Eur Ann Otorhinolaryngol Head Neck Dis. 132:157–159. 2015. View Article : Google Scholar : PubMed/NCBI

11 

De Simone P, Coletti L, Campani D, Falcone A and Filipponi F: Liver transplantation for metastatic sinonasal undifferentiated carcinoma: A case report. Transplant Proc. 40:3821–3822. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Rischin D, Porceddu S, Peters L, Martin J, Corry J and Weih L: Promising results with chemoradiation in patients with sinonasal undifferentiated carcinoma. Head Neck. 26:435–441. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

Journal Cover

June 2019
Volume 17 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
D'Aguanno, V., Ralli, M., Cerbelli, B., Greco, A., & de Vincentiis, M. (2019). Liver metastases from maxillary sinus sinonasal undifferentiated carcinoma: A case report. Oncology Letters, 17, 5811-5814. https://doi.org/10.3892/ol.2019.10251
MLA
D'Aguanno, V., Ralli, M., Cerbelli, B., Greco, A., de Vincentiis, M."Liver metastases from maxillary sinus sinonasal undifferentiated carcinoma: A case report". Oncology Letters 17.6 (2019): 5811-5814.
Chicago
D'Aguanno, V., Ralli, M., Cerbelli, B., Greco, A., de Vincentiis, M."Liver metastases from maxillary sinus sinonasal undifferentiated carcinoma: A case report". Oncology Letters 17, no. 6 (2019): 5811-5814. https://doi.org/10.3892/ol.2019.10251