Pathological analysis of the superior mesenteric artery boundary in preoperative computed tomography of resectable pancreatic head adenocarcinoma

  • Authors:
    • Meng Lu
    • Chun‑Hui Yuan
    • Ling‑Fu Zhang
    • Lian‑Yuan Tao
    • Ying Peng
    • Li‑Mei Guo
    • Gang Li
    • Dian‑Rong Xiu
  • View Affiliations

  • Published online on: April 18, 2019     https://doi.org/10.3892/ol.2019.10269
  • Pages: 5711-5720
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Abstract

The aim of the present study was to evaluate the biological and prognostic implications of the superior mesenteric artery (SMA) boundary on preoperative abdominal contrast‑enhanced computed tomography (CE‑CT) for resectable adenocarcinoma of the pancreatic head. A total of 121 patients treated over a 6‑year period at Peking University Third Hospital (Beijing, China) were included in the present study. The pattern of the SMA boundary was investigated on preoperative CE‑CT and detailed pathological analysis of the extrapancreatic plexus [the pancreatic head plexus II (PLX‑II) located on the right edge of the SMA] was performed. The results revealed that the radiological SMA boundary was associated with the grade of parasympathetic neurogenesis (P=0.014) in PLX‑II, and was predictive of postoperative disease‑free survival (P=0.014) and liver metastasis (P=0.013). Therefore, it was proposed that extrapancreatic parasympathetic neurogenesis may account for the different patterns of the SMA boundary on preoperative abdominal CE‑CT, and affect the prognosis, particularly for liver metastasis in resectable pancreatic head adenocarcinoma.

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June 2019
Volume 17 Issue 6

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Copy and paste a formatted citation
APA
Lu, M., Yuan, C., Zhang, L., Tao, L., Peng, Y., Guo, L. ... Xiu, D. (2019). Pathological analysis of the superior mesenteric artery boundary in preoperative computed tomography of resectable pancreatic head adenocarcinoma. Oncology Letters, 17, 5711-5720. https://doi.org/10.3892/ol.2019.10269
MLA
Lu, M., Yuan, C., Zhang, L., Tao, L., Peng, Y., Guo, L., Li, G., Xiu, D."Pathological analysis of the superior mesenteric artery boundary in preoperative computed tomography of resectable pancreatic head adenocarcinoma". Oncology Letters 17.6 (2019): 5711-5720.
Chicago
Lu, M., Yuan, C., Zhang, L., Tao, L., Peng, Y., Guo, L., Li, G., Xiu, D."Pathological analysis of the superior mesenteric artery boundary in preoperative computed tomography of resectable pancreatic head adenocarcinoma". Oncology Letters 17, no. 6 (2019): 5711-5720. https://doi.org/10.3892/ol.2019.10269