Open Access

Desmoplastic melanoma: Demographic and clinicopathological features and disease‑specific prognostic factors

  • Authors:
    • Ping Shi
    • Zhe Xu
    • Xin Lei
    • Feiluore Yibulayin
    • Alimujiang Wushou
  • View Affiliations

  • Published online on: April 17, 2019     https://doi.org/10.3892/ol.2019.10259
  • Pages: 5619-5627
  • Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Desmoplastic melanoma (DM) is a rare morphological subtype of melanoma that remains uncharacterized. The aim of the present study was to investigate the incidence of DM, its general demographics, clinicopathological features and disease‑specific prognostic factors. DM cases were sampled from the Surveillance, Epidemiology and End Results (SEER) program from between 1973 and 2017. A total of 3,657 cases (median age, 68 years) were identified. The results indicated that DM primarily occurred in Caucasian subjects, with a male‑to‑female ratio of 2:1. Statistically significant overall survival (OS) and disease‑specific survival (DSS) rate differences were identified according to sex, age, treatment, T stage, N stage and SEER historic tumor stage (P<0.05). In multivariate Cox regression analysis, age >68 years, male sex, American Joint Committee on Cancer (AJCC) stage II and III, and SEER historic tumor stage of the regional tumor were all factors associated with poorer OS and DSS rates. The findings also revealed that surgical treatment was associated with favorable DSS and OS rates. In conclusion, DM occurred primarily in Caucasian subjects of 60‑80 years of age, with predominance in males. Furthermore, age, sex, AJCC stage, SEER historic tumor stage and surgical treatment were identified as independent prognostic factors of DM in terms of DSS and OS.

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June 2019
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Copy and paste a formatted citation
APA
Shi, P., Xu, Z., Lei, X., Yibulayin, F., & Wushou, A. (2019). Desmoplastic melanoma: Demographic and clinicopathological features and disease‑specific prognostic factors. Oncology Letters, 17, 5619-5627. https://doi.org/10.3892/ol.2019.10259
MLA
Shi, P., Xu, Z., Lei, X., Yibulayin, F., Wushou, A."Desmoplastic melanoma: Demographic and clinicopathological features and disease‑specific prognostic factors". Oncology Letters 17.6 (2019): 5619-5627.
Chicago
Shi, P., Xu, Z., Lei, X., Yibulayin, F., Wushou, A."Desmoplastic melanoma: Demographic and clinicopathological features and disease‑specific prognostic factors". Oncology Letters 17, no. 6 (2019): 5619-5627. https://doi.org/10.3892/ol.2019.10259