Open Access

Ewing's sarcoma of the cervix: A case report of an unusual diagnosis in pregnancy treated with surgery, adjuvant VIDE and radiotherapy

  • Authors:
    • Anastasios Kyriazoglou
    • Georgios Tsironis
    • Michalis Liontos
    • Alexandra Papakosta
    • Luisa Mahaira
    • Nikolaos Thomakos
    • Georgios Morphopoulos
    • Irene Papaspyrou
    • Aristotelis Bamias
  • View Affiliations

  • Published online on: April 18, 2019     https://doi.org/10.3892/ol.2019.10267
  • Pages: 5529-5535
  • Copyright: © Kyriazoglou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ewing's sarcoma of the cervix is a rare entity and presents with considerable challenges in diagnosis and therapy. Herein, we report a case of a cervical Ewing's sarcoma presenting with FIGO stage Ib, diagnosed during the first trimester of the patient's pregnancy. Imaging with CT scans, MRI of her abdomen and PET‑CT verified the locoregional extension of the tumor. The diagnosis was confirmed by immunohistochemistry and molecular analysis. Fluorescence in situ hybridization and RT‑PCR detected the pathognomonic EWS/FLI fusion gene. Favorable prognostic factors regarding the stage, clinocopathological and molecular characteristics of the tumor are also described. Due to the rarity of the disease, at present, there is no universal consensus on the optimal therapeutic approach. The literature has been reviewed and the therapeutic schemes and available clinical data have been discussed. The patient presented in this case report was treated aggressively with tri‑modality therapy and underwent radical hysterectomy followed by adjuvant chemotherapy with Vincristine‑Ifosfamide‑Doxorubicin‑Etoposide and radiotherapy. The patient remains free of this disease 42 months following the diagnosis of her tumor.

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June 2019
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Copy and paste a formatted citation
APA
Kyriazoglou, A., Tsironis, G., Liontos, M., Papakosta, A., Mahaira, L., Thomakos, N. ... Bamias, A. (2019). Ewing's sarcoma of the cervix: A case report of an unusual diagnosis in pregnancy treated with surgery, adjuvant VIDE and radiotherapy. Oncology Letters, 17, 5529-5535. https://doi.org/10.3892/ol.2019.10267
MLA
Kyriazoglou, A., Tsironis, G., Liontos, M., Papakosta, A., Mahaira, L., Thomakos, N., Morphopoulos, G., Papaspyrou, I., Bamias, A."Ewing's sarcoma of the cervix: A case report of an unusual diagnosis in pregnancy treated with surgery, adjuvant VIDE and radiotherapy". Oncology Letters 17.6 (2019): 5529-5535.
Chicago
Kyriazoglou, A., Tsironis, G., Liontos, M., Papakosta, A., Mahaira, L., Thomakos, N., Morphopoulos, G., Papaspyrou, I., Bamias, A."Ewing's sarcoma of the cervix: A case report of an unusual diagnosis in pregnancy treated with surgery, adjuvant VIDE and radiotherapy". Oncology Letters 17, no. 6 (2019): 5529-5535. https://doi.org/10.3892/ol.2019.10267