Open Access

lncRNA MALAT1 overexpression promotes proliferation, migration and invasion of gastric cancer by activating the PI3K/AKT pathway

  • Authors:
    • Kongxi Zhu
    • Qing Ren
    • Yanying Zhao
  • View Affiliations

  • Published online on: April 15, 2019     https://doi.org/10.3892/ol.2019.10253
  • Pages: 5335-5342
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding RNA (lncRNA) has been implicated in various types of human cancer. However, the role of lncRNA metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) in gastric cancer remains unclear. In the present study, MALAT1 expression was significantly upregulated in gastric tumors compared with adjacent healthy tissue in patients with gastric cancer. Furthermore, MALAT1 plasma expression was higher in patients with gastric cancer compared with healthy controls and was found to have prognostic and diagnostic value independent of patients' lifestyle choices. Cell proliferation assay and Transwell migration and invasion results indicated that the overexpression of MALAT1 resulted in increased proliferation, migration and invasion of gastric cancer cells in vitro, possibly through activation of the phosphoinositide 3‑kinase/protein kinase B pathway.

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June 2019
Volume 17 Issue 6

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Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Zhu, K., Ren, Q., & Zhao, Y. (2019). lncRNA MALAT1 overexpression promotes proliferation, migration and invasion of gastric cancer by activating the PI3K/AKT pathway. Oncology Letters, 17, 5335-5342. https://doi.org/10.3892/ol.2019.10253
MLA
Zhu, K., Ren, Q., Zhao, Y."lncRNA MALAT1 overexpression promotes proliferation, migration and invasion of gastric cancer by activating the PI3K/AKT pathway". Oncology Letters 17.6 (2019): 5335-5342.
Chicago
Zhu, K., Ren, Q., Zhao, Y."lncRNA MALAT1 overexpression promotes proliferation, migration and invasion of gastric cancer by activating the PI3K/AKT pathway". Oncology Letters 17, no. 6 (2019): 5335-5342. https://doi.org/10.3892/ol.2019.10253