Open Access

Protective effect of gonadotropin‑releasing hormone agonist against chemotherapy‑induced ovarian dysfunction: A meta‑analysis

  • Authors:
    • Fei Zheng
    • Bin Zhu
    • Qingjing Feng
    • Lili Wu
    • Yuechong Cui
    • Yumo Liu
    • Yingqian Wang
  • View Affiliations

  • Published online on: April 15, 2019     https://doi.org/10.3892/ol.2019.10252
  • Pages: 5319-5326
  • Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The protective effects of gonadotropin‑releasing hormone agonist (GnRHa) against ovarian chemotherapy induced‑toxicity have not completely been demonstrated and the impact of chemotherapy on ovarian dysfunction remains unclear. The present meta‑analysis aimed to evaluate the efficiency of GnRHa and to determine whether GnRHa could influence the long‑term survival rate of patients with cancer. A total of 12 clinical randomized controlled trials were included, consisting of 1,413 patients who were divided into the GnRHa group (n=705) and the control group (n=708). The meta‑analysis revealed that GnRHa may significantly improve the menstrual function recovery rate in patients who received chemotherapy [RR=1.29, 95% confidence interval (CI)=1.09‑1.54, P=0.004] and reduce the rate of premature ovarian failure (RR=0.47, 95% CI=0.31‑0.71, P=0.0004). However, it had no effect on the pregnancy rate (RR=1.40, 95% CI=0.98‑1.98, P=0.06), on the rate of disease‑free survival and overall survival of patients (disease‑free survival rate: RR=1.04, 95% CI=0.95‑1.13, P=0.40; overall survival rate: RR=1.02, 95% CI=0.90‑1.16, P=0.72). In conclusion, GnRHa may reduce chemotherapy‑induced ovarian dysfunction without compromising or influencing the therapeutic effects of chemotherapy.
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June 2019
Volume 17 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Zheng, F., Zhu, B., Feng, Q., Wu, L., Cui, Y., Liu, Y., & Wang, Y. (2019). Protective effect of gonadotropin‑releasing hormone agonist against chemotherapy‑induced ovarian dysfunction: A meta‑analysis. Oncology Letters, 17, 5319-5326. https://doi.org/10.3892/ol.2019.10252
MLA
Zheng, F., Zhu, B., Feng, Q., Wu, L., Cui, Y., Liu, Y., Wang, Y."Protective effect of gonadotropin‑releasing hormone agonist against chemotherapy‑induced ovarian dysfunction: A meta‑analysis". Oncology Letters 17.6 (2019): 5319-5326.
Chicago
Zheng, F., Zhu, B., Feng, Q., Wu, L., Cui, Y., Liu, Y., Wang, Y."Protective effect of gonadotropin‑releasing hormone agonist against chemotherapy‑induced ovarian dysfunction: A meta‑analysis". Oncology Letters 17, no. 6 (2019): 5319-5326. https://doi.org/10.3892/ol.2019.10252