Open Access

TUSC3 as a potential biomarker for prognosis in clear cell renal cell carcinoma

  • Authors:
    • Youji Yan
    • Zhongjun Chen
    • Yixiang Liao
    • Jiajie Zhou
  • View Affiliations

  • Published online on: March 19, 2019     https://doi.org/10.3892/ol.2019.10161
  • Pages: 5073-5079
  • Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to explore the expression levels of tumor suppressor candidate 3 (TUSC3) in human clear cell renal cell carcinoma (ccRCC) and its clinical value. Immunohistochemical staining, western blotting and reverse transcription‑quantitative polymerase chain reaction were used to detect TUSC3 expression in paracancerous normal tissues and ccRCC tissues. The tissues were derived from the pathological specimens of 54 patients with ccRCC. Additionally, associations among TUSC3 expression and histological grade and clinicopathological staging of ccRCC were investigated. The results of these comparisons revealed that TUSC3 expression in ccRCC tissues was significantly lower than that in paracancerous tissues (P<0.05). TUSC3 expression in the high differentiation group was higher than that in the median and low differentiation groups (P<0.05). Expression levels of TUSC3 in stage I and II tissues were higher than those in stage III and IV tissues (P<0.05). The expression levels of TUSC3 in the lymph node metastasis group were lower than those in the non‑lymph node metastasis group (P<0.05). In conclusion, the expression levels of TUSC3 in human ccRCC tissues were downregulated compared with those found in normal human renal tissue, and TUSC3 may inhibit the progression of ccRCC. Furthermore, the TUSC3 gene may be used as a promising tumor marker for the early diagnosis and prognosis of ccRCC.
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June 2019
Volume 17 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Yan, Y., Chen, Z., Liao, Y., & Zhou, J. (2019). TUSC3 as a potential biomarker for prognosis in clear cell renal cell carcinoma . Oncology Letters, 17, 5073-5079. https://doi.org/10.3892/ol.2019.10161
MLA
Yan, Y., Chen, Z., Liao, Y., Zhou, J."TUSC3 as a potential biomarker for prognosis in clear cell renal cell carcinoma ". Oncology Letters 17.6 (2019): 5073-5079.
Chicago
Yan, Y., Chen, Z., Liao, Y., Zhou, J."TUSC3 as a potential biomarker for prognosis in clear cell renal cell carcinoma ". Oncology Letters 17, no. 6 (2019): 5073-5079. https://doi.org/10.3892/ol.2019.10161