Open Access

Study on value of ultrasonic elastography in diagnosis of clinical staging of cervical cancer and efficacy evaluation of radiotherapy

  • Authors:
    • Yingying Zhang
    • Yuanyuan Yan
    • Yuejie Yang
  • View Affiliations

  • Published online on: March 26, 2019     https://doi.org/10.3892/ol.2019.10190
  • Pages: 4901-4906
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of this study was to investigate the application of ultrasonic elastography in the diagnosis of the clinical staging of cervical cancer (CC) and its evaluation value of the treatment effect of CC. A total of 160 suspected CC patients treated in our hospital from September 2016 to March 2018 were collected. Transvaginal conventional ultrasound and ultrasonic elastography were performed on patients to compare the results of the two in the diagnosis of the pathology and clinical staging of CC. Radiotherapy was used for patients confirmed as CC75 in 160 suspected CC patients. The value difference of strain ratio (SR) between conventional ultrasound and elastic ultrasound in the efficacy evaluation of CC patients was compared. The sensitivity (94.67%), specificity (92.94%) and diagnostic accordance rate (93.75%) of ultrasonic elastography for CC were significantly higher than those of conventional ultrasound, with a statistically significant difference (P<0.001). The sensitivity and diagnostic accordance rate of ultrasonic elastography for the pathological diagnosis of CC in stage III and IV were significantly higher than those of conventional ultrasound, with a statistically significant difference (P<0.05). The sensitivity, specificity and diagnostic accordance rate of elastic ultrasound SR value in the efficacy evaluation of radiotherapy in CC patients were higher than those of conventional ultrasound. Except for the specificity, the other two P-values were <0.05, with a statistically significant difference. The elastography images of different stages of CC have some characteristic features. Ultrasonic elastography has a certain clinical value for the diagnosis and efficacy evaluation of CC.

References

1 

Waggoner SE: Cervical cancer. Lancet. 361:2217–2225. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Sankaranarayanan R, Joshi S, Muwonge R, Esmy PO, Basu P, Prabhu P, Bhatla N, Nene BM, Shaw J, Poli URR, et al Indian HPV vaccine study group, : Can a single dose of human papillomavirus (HPV) vaccine prevent cervical cancer? Early findings from an Indian study. Vaccine. 36:4783–4791. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Liu Y, Zhang L, Zhao G, Che L, Zhang H and Fang J: The clinical research of Thinprep Cytology Test (TCT) combined with HPV-DNA detection in screening cervical cancer. Cell Mol Biol. 63:92–95. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Fuglsang K, Haldorsen IS, Avall-Lundqvist E, Lindahl G, Roed H, Woie K, Pakarinen P, Thoroddsen A, Anttila M and Blaakaer J: Cervical cancer staging, pretreatment planning, and surgical treatment in the Nordic countries-Survey from the Surgical Subcommittee of the Nordic Society of Gynecological Oncology. Acta Obstet Gynecol Scand. 97:1178–1184. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Csutak C, Badea R, Bolboaca SD, Ordeanu C, Nagy VM, Fekete Z, Chiorean L and Dudea SM: Multimodal endocavitary ultrasound versus MRI and clinical findings in pre- and post-treatment advanced cervical cancer. Preliminary report. Med Ultrason. 18:75–81. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Cosgrove D, Piscaglia F, Bamber J, Bojunga J, Correas JM, Gilja OH, Klauser AS, Sporea I, Calliada F, Cantisani V, et al EFSUMB, : EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 2: Clinical applications. Ultraschall Med. 34:238–253. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Zhi H, Xiao XY, Yang HY, Ou B, Wen YL and Luo BM: Ultrasonic elastography in breast cancer diagnosis: Strain ratio vs 5-point scale. Acad Radiol. 17:1227–1233. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Brodersen J: High incidence of cervical cancer in women over 60 is likely due to less intensive cervical screening in this generation of women. BMJ Evid Based Med. 23:372018. View Article : Google Scholar : PubMed/NCBI

9 

Wu ES, Jeronimo J and Feldman S: Barriers and challenges to treatment alternatives for early-stage cervical cancer in lower-resource settings. J Glob Oncol. 3:572–582. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Matsuo K, Shimada M, Yamaguchi S, Kanao H, Nakanishi T, Saito T, Kamiura S, Iwata T, Mikami M and Sugiyama T: Identifying a candidate population for ovarian conservation in young women with clinical stage IB-IIB cervical cancer. Int J Cancer. 142:1022–1032. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Santin AD, Zhan F, Bignotti E, Siegel ER, Cané S, Bellone S, Palmieri M, Anfossi S, Thomas M, Burnett A, et al: Gene expression profiles of primary HPV16- and HPV18-infected early stage cervical cancers and normal cervical epithelium: Identification of novel candidate molecular markers for cervical cancer diagnosis and therapy. Virology. 331:269–291. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Sangwa-Lugoma G, Mahmud S, Nasr SH, Liaras J, Kayembe PK, Tozin RR, Drouin P, Lorincz A, Ferenczy A and Franco EL: Visual inspection as a cervical cancer screening method in a primary health care setting in Africa. Int J Cancer. 119:1389–1395. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Zhao FH, Lewkowitz AK, Chen F, Lin MJ, Hu SY, Zhang X, Pan QJ, Ma JF, Niyazi M, Li CQ, et al: Pooled analysis of a self-sampling HPV DNA Test as a cervical cancer primary screening method. J Natl Cancer Inst. 104:178–188. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Zhu J, Norman I, Elfgren K, Gaberi V, Hagmar B, Hjerpe A and Andersson S: A comparison of liquid-based cytology and Pap smear as a screening method for cervical cancer. Oncol Rep. 18:157–160. 2007.PubMed/NCBI

15 

Huang WC, Yang JM, Yang YC and Yang SH: Ultrasonographic characteristics and cystoscopic correlates of bladder wall invasion by endophytic cervical cancer. Ultrasound Obstet Gynecol. 27:680–686. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Ma X, Li Q, Wang JL, Shao J, Zhu YC, Ding W, Zhang HS, Wang HY and Shen JK: Comparison of elastography based on transvaginal ultrasound and MRI in assessing parametrial invasion of cervical cancer. Clin Hemorheol Microcirc. 66:27–35. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Salvo G, Ramirez PT, Levenback CF, Munsell MF, Euscher ED, Soliman PT and Frumovitz M: Sensitivity and negative predictive value for sentinel lymph node biopsy in women with early-stage cervical cancer. Gynecol Oncol. 145:96–101. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Takagi H, Sakamoto J, Osaka Y, Shibata T, Fujita S and Sasagawa T: Usefulness of the maximum standardized uptake value for the diagnosis and staging of patients with cervical cancer undergoing positron emission tomography/computed tomography. Medicine (Baltimore). 97:e98562018. View Article : Google Scholar : PubMed/NCBI

19 

Fischerova D, Cibula D, Stenhova H, Vondrichova H, Calda P, Zikan M, Freitag P, Slama J, Dundr P and Belacek J: Transrectal ultrasound and magnetic resonance imaging in staging of early cervical cancer. Int J Gynecol Cancer. 18:766–772. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Lorenz A, Ermert H, Sommerfeld HJ, Garcia-Schürmann M, Senge T and Philippou S: Ultrasound elastography of the prostate. A new technique for tumor detection. Ultraschall Med. 21:8–15. 2000.(In German). PubMed/NCBI

21 

Sikdar S, Shah JP, Gebreab T, Yen RH, Gilliams E, Danoff J and Gerber LH: Novel applications of ultrasound technology to visualize and characterize myofascial trigger points and surrounding soft tissue. Arch Phys Med Rehabil. 90:1829–1838. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

Journal Cover

June 2019
Volume 17 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Zhang, Y., Yan, Y., & Yang, Y. (2019). Study on value of ultrasonic elastography in diagnosis of clinical staging of cervical cancer and efficacy evaluation of radiotherapy. Oncology Letters, 17, 4901-4906. https://doi.org/10.3892/ol.2019.10190
MLA
Zhang, Y., Yan, Y., Yang, Y."Study on value of ultrasonic elastography in diagnosis of clinical staging of cervical cancer and efficacy evaluation of radiotherapy". Oncology Letters 17.6 (2019): 4901-4906.
Chicago
Zhang, Y., Yan, Y., Yang, Y."Study on value of ultrasonic elastography in diagnosis of clinical staging of cervical cancer and efficacy evaluation of radiotherapy". Oncology Letters 17, no. 6 (2019): 4901-4906. https://doi.org/10.3892/ol.2019.10190