Open Access

Evaluation of the benefit of post‑mastectomy radiotherapy in patients with early‑stage breast cancer: A propensity score matching study

  • Authors:
    • Wenjie Shi
    • Youhong Luo
    • Dongkang Zhao
    • Hao Huang
    • Weiyi Pang
  • View Affiliations

  • Published online on: March 29, 2019     https://doi.org/10.3892/ol.2019.10197
  • Pages: 4851-4858
  • Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to evaluate the significance of post‑mastectomy radiotherapy (PMRT) in patients with early stage (T1‑2) breast cancer. The Surveillance, Epidemiology, and End Results database was searched, and data on female patients with early stage (T1‑2) breast cancer with 1‑3 positive axillary lymph nodes (LNs) were extracted. Patients were subdivided into two groups: Those who had received PMRT and those who had not (no PMRT). Data from the two groups were analyzed in order to identify associations between PMRT status, breast cancer‑specific survival (BCSS) probability and overall survival (OS) probability using multivariate Cox proportional hazards regression and propensity score matching models. A total of 7,316 patients were included in the analysis. Prior to propensity score matching, outcome probabilities were increased in the PMRT group, compared with the no PMRT group (BCSS probabilities: 92.0 vs. 90.1%, respectively, P=0.015; OS probabilities: 89.8 vs. 86.0%, respectively, P<0.001). In multivariate analyses, tumor location was not identified as being a risk factor for BCSS (hazard ratio, 0.917; 95% confidence interval, 0.772‑1.090; P=0.326). Following propensity score matching, differences between the two treatment groups (PMRT and no PMRT) in terms of their BCSS scores remained significant (93.7 vs. 90.1%, respectively; P=0.007). Compared with the no PMRT group, the OS probabilities of the PMRT group were increased (89.4 vs. 86.0%; P=0.025). In conclusion, the present results indicated that PMRT may benefit the prognosis of patients with breast cancer with early stage disease (T1‑2), and those with one to three positive axillary LNs.

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Copy and paste a formatted citation
APA
Shi, W., Luo, Y., Zhao, D., Huang, H., & Pang, W. (2019). Evaluation of the benefit of post‑mastectomy radiotherapy in patients with early‑stage breast cancer: A propensity score matching study. Oncology Letters, 17, 4851-4858. https://doi.org/10.3892/ol.2019.10197
MLA
Shi, W., Luo, Y., Zhao, D., Huang, H., Pang, W."Evaluation of the benefit of post‑mastectomy radiotherapy in patients with early‑stage breast cancer: A propensity score matching study". Oncology Letters 17.6 (2019): 4851-4858.
Chicago
Shi, W., Luo, Y., Zhao, D., Huang, H., Pang, W."Evaluation of the benefit of post‑mastectomy radiotherapy in patients with early‑stage breast cancer: A propensity score matching study". Oncology Letters 17, no. 6 (2019): 4851-4858. https://doi.org/10.3892/ol.2019.10197