Differential expression profiles of the transcriptome in bone marrow‑derived cells in lung cancer revealed by next generation sequencing and bioinformatics
- Wei‑An Chang
- Ying‑Ming Tsai
- Yu‑Chen Tsai
- Cheng‑Ying Wu
- Kuo‑Feng Chang
- Chi‑Tun Lien
- Jen‑Yu Hung
- Ya‑Ling Hsu
- Po‑Lin Kuo
Affiliations: Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C., Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, R.O.C., Welgene Biotech, Inc., Taipei 115, Taiwan, R.O.C., Department of Internal Medicine, Kaohsiung Municipal United Hospital, Kaohsiung 804, Taiwan, R.O.C., Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C.
- Published online on: February 28, 2019 https://doi.org/10.3892/ol.2019.10085
Copyright: © Chang
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A pre‑metastatic niche (PMN) facilitates cancer metastasis through mobilization and recruitment of bone marrow‑derived cells (BMDCs) and associated factors. In bone marrow, hematogenous cells, including osteoclasts, macrophages and lymphocytes, and mesenchymal cells, including mesenchymal stem cells, osteoblasts and adipocytes, are involved in PMN formation. Patients with lung cancer and metastasis have a poor prognosis and shortened median survival time. Bone marrow has been considered fertile ground for dormant and proliferating tumor cells, and mobilizing and recruiting BMDCs and immune cells can establish a PMN. However, the role of BMDCs in PMN formation is not yet fully understood. The present study aimed to investigate the association between BMDCs and PMN in bone marrow tissue samples. The results demonstrated that bone marrow served an important role in lung cancer progression and that eight pathways were potentially involved, including ‘T‑cell receptor signaling pathway’, ‘osteoclast differentiation’, ‘MAPK signaling pathway’, ‘VEGF signaling pathway’, ‘leukocyte transendothelial migration’, ‘signaling pathways regulating the pluripotency of stem cells’, ‘oxytocin signaling pathway’ and ‘cell adhesion molecules (CAMs)’. In addition, the present study investigated the role of BMDCs in facilitating lung cancer metastasis. In conclusion, the results from the present study suggested that molecular alterations in gene expression may provide a novel signature in lung cancer, which may aid in the development of novel diagnostic and therapeutic strategies for patients with lung cancer and bone metastasis.