Association of pre-miRNA-146a rs2910164 and pre‑miRNA-499 rs3746444 polymorphisms and susceptibility to rheumatoid arthritis

  • Authors:
    • Mohammad Hashemi
    • Ebrahim Eskandari-Nasab
    • Zahra Zakeri
    • Mahdi Atabaki
    • Gholamreza Bahari
    • Mahdi Jahantigh
    • Mohsen Taheri
    • Saeid Ghavami
  • View Affiliations

  • Published online on: November 8, 2012     https://doi.org/10.3892/mmr.2012.1176
  • Pages: 287-291
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Abstract

Single nucleotide polymorphisms in pre‑microRNA (miRNA) may alter miRNA expression levels or processing and contribute to susceptibility in a wide range of diseases. The present study aimed to evaluate the possible association between rs2910164 and rs3746444 of the pre-miRNA (hsa-mir-146a and hsa-mir-499) polymorphisms and susceptibility to rheumatoid arthritis (RA) in an Iranian population. This case-control study was performed on 104 patients with RA and 110 healthy individuals. Tetra amplification refractory mutation system-polymerase chain reaction was used to genotype the hsa-mir-499 rs3746444 and hsa-mir-146a rs2910164 polymorphisms. The hsa-mir-499 rs3746444 polymorphism was a risk factor for predisposition to RA in codominant [TT vs. TC: odds ratio (OR), 2.11; 95% confidence interval (CI), 1.08-4.11; p=0.029; TT vs. CC: OR, 3.88; 95% CI, 1.68-8.98; p=0.002], dominant (TT vs. TC-CC: OR, 2.64; 95% CI, 1.48-4.72; p=0.001) and recessive (TC-CC vs. CC: OR, 3.05; 95% CI, 1.36-6.83; p=0.007) tested inheritance models. In addition, the rs3746444 C allele was a risk factor for RA (OR, 2.49; 95% CI, 1.63-3.81; p<0.0001). No significant difference was found between the groups concerning the rs2910164 polymorphism (χ2=0.348, p=0.841). Our findings demonstrated that the hsa-mir-499 rs3746444, but not mir-146a rs2910164, polymorphism is associated with an increased RA risk in a sample of the Iranian population. Larger studies with different ethnicities are required to validate our findings.

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APA
Hashemi, M., Eskandari-Nasab, E., Zakeri, Z., Atabaki, M., Bahari, G., Jahantigh, M. ... Ghavami, S. (2013). Association of pre-miRNA-146a rs2910164 and pre‑miRNA-499 rs3746444 polymorphisms and susceptibility to rheumatoid arthritis. Molecular Medicine Reports, 7, 287-291. https://doi.org/10.3892/mmr.2012.1176
MLA
Hashemi, M., Eskandari-Nasab, E., Zakeri, Z., Atabaki, M., Bahari, G., Jahantigh, M., Taheri, M., Ghavami, S."Association of pre-miRNA-146a rs2910164 and pre‑miRNA-499 rs3746444 polymorphisms and susceptibility to rheumatoid arthritis". Molecular Medicine Reports 7.1 (2013): 287-291.
Chicago
Hashemi, M., Eskandari-Nasab, E., Zakeri, Z., Atabaki, M., Bahari, G., Jahantigh, M., Taheri, M., Ghavami, S."Association of pre-miRNA-146a rs2910164 and pre‑miRNA-499 rs3746444 polymorphisms and susceptibility to rheumatoid arthritis". Molecular Medicine Reports 7, no. 1 (2013): 287-291. https://doi.org/10.3892/mmr.2012.1176