Open Access

CFHR1 is a potentially downregulated gene in lung adenocarcinoma

  • Authors:
    • Geting Wu
    • Yuanliang Yan
    • Xiang Wang
    • Xinxin Ren
    • Xi Chen
    • Shuangshuang Zeng
    • Jie Wei
    • Long Qian
    • Xue Yang
    • Chunlin Ou
    • Wei Lin
    • Zhicheng Gong
    • Jianhua Zhou
    • Zhijie Xu
  • View Affiliations

  • Published online on: September 3, 2019     https://doi.org/10.3892/mmr.2019.10644
  • Pages: 3642-3648
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

There is increasing evidence that human complement factor H‑related protein 1 (CFHR1) plays a crucial role in the development of malignant diseases. However, few studies have identified the roles of CFHR1 in the occurrence and prognosis of lung adenocarcinoma (LADC). In the present study, comprehensive bioinformatic analyses of data obtained from the Oncomine platform, UALCAN and Gene Expression Profiling Interactive Analysis (GEPIA) demonstrated that CFHR1 expression is significantly reduced in both LADC tissues and cancer cells. The patients presenting with downregulation of CFHR1 had significantly lower overall survival (OS) and post progression survival (PPS) times. Through analysis of the datasets from Gene Expression Omnibus database, we found that the compound actinomycin D promoted CFHR1 expression, further displaying the cytotoxic effect in the LADC cell line A549. In addition, the expression level of CFHR1 in the cisplatin‑resistant LADC cell line CDDP‑R (derived from H460) was also significantly reduced. Our research demonstrated that low levels of CFHR1 are specifically found in LADC samples, and CFHR1 could serve as a potential therapeutic target for this subset of lung cancers. Determination of the detailed roles of CFHR1 in LADC biology could provide insightful information for further investigations.

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October 2019
Volume 20 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
APA
Wu, G., Yan, Y., Wang, X., Ren, X., Chen, X., Zeng, S. ... Xu, Z. (2019). CFHR1 is a potentially downregulated gene in lung adenocarcinoma. Molecular Medicine Reports, 20, 3642-3648. https://doi.org/10.3892/mmr.2019.10644
MLA
Wu, G., Yan, Y., Wang, X., Ren, X., Chen, X., Zeng, S., Wei, J., Qian, L., Yang, X., Ou, C., Lin, W., Gong, Z., Zhou, J., Xu, Z."CFHR1 is a potentially downregulated gene in lung adenocarcinoma". Molecular Medicine Reports 20.4 (2019): 3642-3648.
Chicago
Wu, G., Yan, Y., Wang, X., Ren, X., Chen, X., Zeng, S., Wei, J., Qian, L., Yang, X., Ou, C., Lin, W., Gong, Z., Zhou, J., Xu, Z."CFHR1 is a potentially downregulated gene in lung adenocarcinoma". Molecular Medicine Reports 20, no. 4 (2019): 3642-3648. https://doi.org/10.3892/mmr.2019.10644