Open Access

Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence

  • Authors:
    • Penghui Song
    • Jing Hu
    • Xijin Liu
    • Xuejun Deng
  • View Affiliations

  • Published online on: April 30, 2019     https://doi.org/10.3892/mmr.2019.10202
  • Pages: 5433-5439
  • Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Previous studies have indicated that the adenosine triphosphate‑sensitive homomeric P2X7 receptor (P2X7R) plays an important role and exhibits therapeutic potential in a number of brain disorders, including temporal lobe epilepsy (TLE). The aim of the present study was to assess the expression of P2X7R, glutamate (GLU) and glial fibrillary acidic protein (GFAP) in the temporal neocortex and hippocampus of rats with lithium‑pilocarpine‑induced epilepsy as well as in patients with intractable TLE. The results demonstrated that the levels of P2X7R, GLU and GFAP were significantly upregulated in rats with spontaneous recurrent seizures, whereas they were reduced in rats that were treated with brilliant blue G (BBG), a P2X7R antagonist. To the best of our knowledge, the present study is also the first to demonstrate that P2X7R expression was elevated in patients with intractable TLE. These findings suggest that P2X7R plays a key role in the development of TLE and that BBG treatment may be a promising therapeutic strategy for TLE.

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Copy and paste a formatted citation
APA
Song, P., Hu, J., Liu, X., & Deng, X. (2019). Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence. Molecular Medicine Reports, 19, 5433-5439. https://doi.org/10.3892/mmr.2019.10202
MLA
Song, P., Hu, J., Liu, X., Deng, X."Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence". Molecular Medicine Reports 19.6 (2019): 5433-5439.
Chicago
Song, P., Hu, J., Liu, X., Deng, X."Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence". Molecular Medicine Reports 19, no. 6 (2019): 5433-5439. https://doi.org/10.3892/mmr.2019.10202